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Thrp - Oncology Flashcards

1
Q

5-Fluorouracil

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
FLUORINATED PYRIMIDINE

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2
Q

Capecitabine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
FLUORINATED PYRIMIDINE

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3
Q

Cytarabine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
FLUORINATED PYRIMIDINE

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4
Q

Gemcitabine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
FLUORINATED PYRIMIDINE

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5
Q

Azacytadine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
FLUORINATED PYRIMIDINE

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6
Q

Decitabine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
FLUORINATED PYRIMIDINE

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7
Q

Methotrexate

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
ANTI-FOLATE

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8
Q

Pemetrexed

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
ANTI-FOLATE

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9
Q

6-Mercaptopurine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
PURINE ANTAGONISTS

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10
Q

6-Thioguanine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis

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11
Q

Fludarabine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis

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12
Q

Cladribine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis

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13
Q

Pentostatin

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis

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14
Q

Clofarabine

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
PURINE ANTAGONISTS

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15
Q

Hydroxyurea

A

Antimetabolite: Inhib enzymes necessary for DNA/RNA/ Protein synthesis
Ribonucleotide Reductase Inhibitor

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16
Q

Vincristine

A

VINCA ALKALOID Microtubule-Targeting: Bind to Tubulin

17
Q

Vinblastine

A

VINCA ALKALOID Microtubule-Targeting: Bind to Tubulin

18
Q

Vinorelbine

A

VINCA ALKALOID Microtubule-Targeting: Bind to Tubulin

19
Q

Paclitaxel

A

TAXANE Microtubule-Targeting: Enhance tubulin polymerization which alters normal tubulin fn, preventing cell devision

20
Q

Docetaxel

A

TAXANE Microtubule-Targeting: Enhance tubulin polymerization which alters normal tubulin fn, preventing cell devision

21
Q

Paclitaxel nanoparticle albumin bound

A

TAXANE Microtubule-Targeting: Enhance tubulin polymerization which alters normal tubulin fn, preventing cell devision

22
Q

Estramustine

A

Microtubule-Targeting (own class): binds to microtubules (Structurally combines alkylating agent nor-nitrogen mustard with the hormone estradiol)

23
Q

Cell-cycle Specific Chemo

A

Chemo agents with major activity in a particular phase of the cell cycle
Usually given as continuous infusion over 12-24 hours
Schedule Dependent

24
Q

Cell-cycle non specific Chemo

A

Kill independently of any phase of cycle
Usually bolus injection
Dose Dependent

Therapeutics (10 decks)

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