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Therapeutics > Thrp (HIV) > Flashcards

Thrp (HIV) Flashcards

1
Q

Lamivudine (3TC)

A

Epivir - NRTI
with our without food

Well tolerated

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2
Q

Emtricitabine (FTC)

A

Emtriva - NRTI
with or without food

AE: Hyper-pigmentation of palms and soles

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3
Q

Tenofovir (TDF)

A

Viread - NRTI
With or without food

AE: GI, Renal insufficiency, potential for osteopenia

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4
Q

Zidovudine (ZDV)

A

Retrovir - NRTI

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5
Q

Abacavir (ABC)

A

Ziagen - NRTI
with or without food

Dec Efficacy with VL >100,000 copies/mL DONT USE
AE: Hypersensitivity rxn: DO **HLA-B5701 Testing
MI risk: A weak association, NOT an Absolute CI

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6
Q

Didanosine (ddl)

A

Videx - NRTI

hight risk of AE: Lactic acidosis with hepatic steatosis

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7
Q

Stavudine (d4T)

A

Zerit - NRTI

Greatest AE: Lactic acidosis with hepatic steatosis

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8
Q

Ritonavir (RTV)

A

Norvir - “Booster” (old - Protease Inhibitor)

TAKE AT SAME TIME AS P.I.
AE: GI intolerance, Hepatitis, Peresthesias

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9
Q

Cobicistat

A

In combo’s - “Booster”

TAKE AT SAME TIME AS P.I.
AE: Inc SrCr and get changes is eGFR but not aGFR
GI < RTV (well tolerated)

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10
Q

Tenofovir + Emtricitabine

A

Truvada

Preferred NRTI combo *THE NRTI Back-Bone; always

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11
Q

Abacavir + Lamivudine

A

Epizicom

Alternative to preferred NRTI combo

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12
Q

Zidovudine + Lamivudine

A

Combivir

Alternative to preferred NRTI combo *Preferred in Prego

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13
Q

Efavirenz (EFV)

A

Sustiva - NNRTI *Prefereed in Naive Pts
On and EMPTY stomach (food inc SE)

AE: CNS (vivid dreams, subside due to dec blood [ ] as a result of the auto-induction effect from drug) Skin rash (tx anti-H, Teratogen (NEVER IN PREGO OR POTENTIAL PREGO), Inc LFT/LDL/TC/TG/HDL, False+ for cannabinoid and BDZ

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14
Q

Nevirapine (NVP)

A

Viramune - NNRTI

Preferred in Prego

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15
Q

Delavirdine (DLV)

A

Rescriptor - NNRTI

Inferior NNRTI and NOT USED

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16
Q

Etravirine (ETR)

A

Intelence - NNRTI

Only in Tx-experienced pts (Consider if Resistance)

17
Q

Rilpivirine (TMC278)

A

Edurant - NNRTI *alt. to preffered in Naive Pts
WITH food

AE: Skin rashe (watch and Tx Anti-H) Depressive Ds.

AVOID in pts with VL>100K or CD4<200

18
Q

Efavirenz + Tenofovir + Emtricitabine

A

Atripla * preferred Regim

19
Q

Rilpivirine + Tenofovir + Emtricitabine

A

Complera

20
Q

Atazanavir (ATV)

A

Reyataz - Protease Inhibitor (Always boosted with RTV) Preferred Regimen [Unboosted = alternative] in Tx-Experirenced pts
Take WITH Food
*Only PI that is NOT BID dosing
Preferred in Prego

AE: Best tolerated PI, least hyperlipidemia
N/V, Diarrhea
Gall stone Dz (inc. fluid intake), fat maldistribution (hump) Nephrolithiasis, hyperbilirubenemia

21
Q

Darunavir (DRV)

A

Prezista - Protease Inhibitor (Always boosted with RTV) Preferred Regimen in Tx-Experirenced pts
Take WITH Food
BID

AE: Well tolerated PI, least hyperlipidemia
N/V, Diarrhea
Rash (sulfer moiety, monitor), hepatotoxicity, Fat maldistribution

22
Q

Fosamprenavir (FPV)

A

Lexiva - Protease Inhibitor (Always boosted with RTV)

AE: hyperlipidemia N/V, Diarrhea

23
Q

Lopinavir/Ritonavir

A

Kaletra - Protease Inhibitor (Always boosted with RTV)
Preferred in Prego

AE: hyperlipidemia N/V, Diarrhea

24
Q

Sauinavir (SQV)

A

Invirase - Protease Inhibitor (Always boosted with RTV)

AE: hyperlipidemia N/V, Diarrhea

25
Q

Tipranavir (TPV)

A

Aptivus - Protease Inhibitor (Always boosted with RTV)

AE: hyperlipidemia N/V, Diarrhea

26
Q

Dolutegravir (DTG)

A

Tivicay - Integrase Inhibitor (newest agent but probably be new preferred agent)
With OR without food

AE: Hypersensitivity, insomnia, HA elevated Cr (well tolerated)

27
Q

Elvitegravir (EVG)

A
  • Integrase Inhibitor
    ONLY available as a compnent of “single Tablet Regimen” Stribild (combo = with food)

AE: N/D elevated Cr (Well tolerated

28
Q

Stribild

A

an “STR” - Tenofovir/Emtricitabine/Elvitegravir/Cobicistat
With food
Alternative regimen in Tx-naive pts with CrCl>70mL/min BUT artificial Cr boost??

29
Q

Raltegravir (RAL)

A

Isentress - Integrase Inhibitor **Preferreed agent in Tx-Naive pts (IN COMBO with emtricitabine)
* Can be used in Tx-Experienced pts IF naive to Integrase Inhibitors
With OR without food

AE: N/D, significant HA requiring d/c

30
Q

Enfuvirtide (t20)

A

Fuzeon - Fusion Entry Inhibitor (injection)

Indicated in Tx-Experienced pts only (not used)

31
Q

Maraviroc (MVC)

A

Selzentry - CCR5 antagonist entry inhibitor

Can use in Tx- Naive pts IF* (mosty Tx-experienced)
Use requires “Trofile” co-Receptor assay: Tests to see if virus strain uses CCR5 co-recepter to enter the CD4+ cell - if so can use Rx
If test shows virus is an X4 virus then has mutated to use CXCR4 co-receptor (more virulent)

AE: Cough,

Therapeutics (10 decks)

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