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Therapeutics > Thrp - Cardio 1 Drugs > Flashcards

Thrp - Cardio 1 Drugs Flashcards

1
Q

Wt Loss goal and effect on HTN

A

Goal: BMI 18.5-25.9

SBP Reduction: 5-20 / 10kg

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2
Q

DASH

A

Goal: Fruit, vegi, low fat dairy, reduced sat/total fat

SBP Reduction: 8-14

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3
Q

Na+ intake

A

Goal: <1.5g - 2.3g/day

SBP Reduction: 2-8

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4
Q

Exercise

A

Goal: 30min/day most days of the week

SBP Reduction: 4-9

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5
Q

EtOH consumption

A

Goal: Men <1/day

SBP Reduction: 2-4

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6
Q

Chlorthalidone

A

Thiazide Diuretic:
Tx HTN 1st line (1.5-2 X more potent, lasts longer and better dec in CV outcomes vs HCTZ)

12.5-25mg PO qday AM

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7
Q

Hydrochlorothiazide

A

Thiazide Diuretic:
Tx HTN 1st line

12.5-25mg PO qday AM (50mg=upper limit but 25mg max efficacy)

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8
Q

Bumetanide

A 
Loop Diuretic
Tx HTN (Not 1st choice, god in HF/Edema)

0.5-2mg PO QDAY or BID

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9
Q

Furosemide

A 
Loop Diuretic
Tx HTN (Not 1st choice, god in HF/Edema)

20-80mg PO QDAY or BID

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10
Q

Torsemide

A 
Loop Diuretic
Tx HTN (Not 1st choice, god in HF/Edema)

2.5-10mg PO QDAY.

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11
Q

Amiloride

A

K+ Sparing diuretic
Tx: Prevention of Hypo-K+ IN COMBO with other RAAS drugs/renal insufficiency (week diuretic NOT used to tx HTN alone)

5-10mg QD or BID

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12
Q

Triamterene

A

K+ Sparing diuretic
Tx: Preention of Hypo-K+ IN COMBO with other RAAS drugs/renal insufficiency (week diuretic NOT used to tx HTN alone)

50-100mg QD or BID

Alone is Brand name only: Dyrenium

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13
Q

Benazepril

A

ACE-I

10-40mg QD-BID

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14
Q

Captopril

A

ACE-I

25-100mg BID

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15
Q

Enalapril

A

ACE-I
5-40mg QD-BID

IV Formulation (Enalaprilat IV) 1.25mg q6h

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16
Q

Lisinopril

A

ACE-I

10-40mg QD (closest ace to 24hr ACE)

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17
Q

Ramapril

A

ACE-I

2.5-20mg QD-BID

18
Q

Losartan

A

ARB

25-100mg QD-BID

19
Q

Valsartan

A

ARB
80-320mg QD-BID

Brand Name Only: Diovan

20
Q

Irbesartan

A

ARB

150-300mg QD

21
Q

Candesartan

A

ARB

8-32mg QD

22
Q

Telmisartan

A

ARB
20-80mg QD

Brand Name Only: Micardis

23
Q

Olmesartan

A

ARB
20-40mg QD

Brand Name Only: Benicar

24
Q

Nifedipine

A

Dihydropyridine CCB

SR or XL 30-120mg QD

25
Q

Amlodipine

A

Dihydropyridine CCB

2.5-10mg QD

26
Q

Diltiazem ER

A

Non-Dihydropyridine CCB

120-360mg QD

27
Q

Verapamil

A

Non-Dihydropyridine CCB
IR 80-320mg BID
SR 120-480mg QD-BID

28
Q

Labetalol

A

Nonselective β1 (with α blockade) β-Blocker
Start: 100mg BID

IV formulation

29
Q

Carvedilol

A

Nonselective β1 (with α blockade) β-Blocker
IR 12.5-50mg BID
ER 20-80mg QD

30
Q

Metoprolol

A

β1 selective β-Blocker
(Tartrate) IR 50-200mg BID
(Succinate) XL 100-400mg QD

31
Q

Atenolol

A

β1 selective β-Blocker
25-100mg QD (but does not last 24hrs)

Less evidence for CVD risk reduction

32
Q

Prazosin

A

α1 Blocker

1-20mg BID-TID

33
Q

Terazosin

A

α1 Blocker

1-20mg QD-BID

34
Q

Doxazosin

A

α1 Blocker
1-16mg QD
(inc HF with Rx)

35
Q

Eplerenone

A

Aldosterone Receptor Blockers
50-100mg QD
(more hyper-K vs spiro)

36
Q

Spironolactone

A

Aldosterone Receptor Blockers
25-50mg QD
(more gynecomastia vs eplerenone)

37
Q

Clonidine

A

Centrally Acting HTN Rx: α2 Receptor Agonist
Tab: 0.1-0.8mg BID (short t1/2)
Patch: 0.1-0.3mg Weekly

38
Q

Methyldopa

A

Centrally Acting HTN Rx: Exact MOA unknown but metabolite α-methylnorepinephrine is potent α2 Receptor Agonist
250-1000mg BID to TID

Tx HTN in Pregnancy

39
Q

Reserpine

A

Centrally Acting HTN Rx: depletes catecholamines and 5-HT in brain and adrenal medulla
0.1-0.25mg QD

40
Q

Hydralazine

A

Direct Vasodilator
25-100mg TID-QID

IV and IM formulation

41
Q

Minoxidil

A

Direct Vasodilator

2.5-80mg QD-BID

42
Q

Aliskiren

A

Direct Renin Inhibitor
150-300mg QD

Brand name only: Tekturna

Therapeutics (10 decks)

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