Thrombotic Thrombocytopenic Purpura (TTP) Flashcards
1
Q
Diagnosis:
What is seen on the blood film?
Why may you notice some jaundice? I’m
A
Blood film - fragments
Due to haemolysis?
2
Q
Why do they get organ failure?
What organ is most affected and would give you a clue that it is TTP?
A
Due to microvascular thrombosis
Neurological impairment often a clue in exams!
3
Q
Treatment:
What transfusion would you do?
It may be congenital or acquired.
There is a deficiency of autoimmune attack of ADAMTS13 which usually cleaves VWF.
What other treatment may also be beneficial here?
A
Plasma exchange (PEX)
Immunosuppression - rituximab
