Thrombosis/Thrombophilia Flashcards
Venous thrombosis are best treated with what medication?
systemic anticoagulation (e.g. warfarin)
Arterial thrombosis are best treated with what medication?
antiplatelet agents
What are the 3 most important anticoagulant proteins?
- antithrombin
- Protein C (does bulk of work)
- Protein S (cofactor of protein C)
All hereditary thrombophilias predispose patients to _____ thromboses only.
venous
Why should you NOT send tests for hereditary thrombophilias in hospitalized patients with an acute clot?
testing affected by acute clot and anticoagulant use
In factor V leiden a mutation in factor V results in what?
activated factor V that is resistant to degradation by activated protein C
Females with a hereditary thrombophilia should be advised to take an oral contraceptive made up of only this hormone.
progesterone
in order to diagnose antiphospholipid antibody syndrome (APLS) 1 out of 2 of these requirements must be met
- thrombosis
- recurrent miscarriages in the setting of persistently positive titers
What are the 3 autoantibodies we test for in APLS?
- Lupus anticoagulant test
- anti-cardiolipin antibodies
- anti-beta2 glycoprotein 1
Antiphospholipid antibody syndrome (APLS) is associated with thrombosis in what vascular system?
BOTH venous and arterial
How is Antiphospholipid antibody syndrome (APLS) treated?
indefinite warfarin
A patient appears to be suffering from a superficial thrombophlebitis due to an IV placement. What is the recommended treatment?
a. anticoagulation
b. NSAIDs
c. heat packs
d. both B and C
e. all of the above
d. both B and C
How is a DVT diagnosed?
lower extremity doppler ultrasound
A patient presents with dyspnea, tachycardia. He reported calf tenderness a few days ago. What is the diagnoses?
PE
What is the duration of anticoagulation in a patient with a PROVOKED DVT/PE with primary risk factor now gone?
minimum 3 months
