More questions

Question 1

What natural anticoagulant is required for heparin to work?

Answer 1

antithrombin

Question 2

Why do we need to bridge coumadin?

Answer 2

coumadin will decrease protein C and S so it will cause an acute hypercoagulable state

Question 3

What is the formula to calculate ANC?

Answer 3

ANC = [ (% neutrophils + % band) x WBC]/ 100

Question 4

Elevated LDH, indirect bilirubin, and haptoglobin, combined with anemia is consistent with what?

Answer 4

hemolytic anemia

Question 5

Thalassemia is a _________ problem, while sickle cell is a _________ problem

Answer 5

• thalassemia = quantitative

- sickle cell = qualitative

Question 6

What is the treatment for hereditary spherocytosis?

Answer 6

remove spleen

Question 7

What is the treatment for warm hemolytic anemia (IgG+)?

Answer 7

steroids immunesuppression

Question 8

What is the diagnostic test for G6PD deficiency?

Answer 8

G6PD enzyme level

Question 9

If a patient is receiving a transfusion and develops hives ONLY what do you do?

Answer 9

antihistamines and keep going

Question 10

What is the difference in terms of pathophysiology between ITP and TTP?

Answer 10

• ITP = auto-antibody against platelets

- TTP = deficiency in Adams TS13 which cleaves vWF

Question 11

What is the treatment for TTP?

Answer 11

plasma exchange to give back Adams TS13

Question 12

How do you diagnose TTP?

Answer 12

check Adams TS13 level

Question 13

HUS is typically d/t to what?

Answer 13

E. coli infection

Question 14

How can you use labs to differentiate between HUS and TTP?

Answer 14

TTP will have low Adams TS13 but normal in HUS

Question 15

What is HELLP associated with?

Answer 15

pre-eclampsia in pregnancy

Question 16

How is HELLP treated?

Answer 16

deliver the baby

Question 17

What are the 5 MAHAs discussed in class?

Answer 17

• ITP
• TTP
• HUS
• HELLP
• DIC

Question 18

How can you differentiate DIC from the rest of the MAHAs?

Answer 18

• look at coags they will be prolonged!

Question 19

What are the 2 main consequences of renal disease?

Answer 19

• EPO deficiency causing anemia

- qualitative platelet defect

Question 20

What is the treatment for hereditary hemochromatosis?

Answer 20

phlebotomy

Question 21

How do you a qualitative platelet abnormality secondary to uremia?

Answer 21

• DDAVP to increase factor 8 and vWF

Question 22

There is no risk of spontaneous bleeding until platelet count is how low?

Answer 22

<10-20,000

Question 23

Before initiating workup of new onset thrombocytopenia you must rule out _________________ .

Answer 23

pseudothrombocytopenia

Question 24

How is immune thrombocytopenia diagnosed?

Answer 24

diagnoses of exclusion

BUT on PBS can see large platelets

Question 25

What is the treatment for immune thrombocytopenia?

Answer 25

corticosteroids

Question 26

What is the treatment for DIC?

Answer 26

fix underlying cause

Question 27

What is the clinical pentad consistent with TTP?

Answer 27

• fever
• anemia
• thrombocytopenia
• renal failure
• neurologic dysfunction

Question 28

How is TTP treated?

Answer 28

plasmapheresis with plasma exchange

Question 29

How is HUS diagnosed and treated?

Answer 29

• diagnosed = stool culture for EHEC

- treated = supportive, NO ANTIBIOTICS