Thrombosis lecture Flashcards

1
Q

What is post-thrombotic syndrome?

A

A syndrome characterized by features of chronic venous insufficiency (e.g., pain, edema, venous dilation, ulceration, abnormal skin pigmentation) that develop following a deep vein thrombosis.

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2
Q

What is Virchow’s triad?

A

Alterations in normal blood flow (stasis)
injuries to the vascular endothelium
Alterations in the constitution of blood (hypercoagubility)

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3
Q

Why does the risk of venous thrombosis increase/decrease in pregnancy?

A

state of hypercoagubility

  • Increased clotting factors
  • decreased fibrinolysis
  • increased platelet adhesiveness

Venous stasis resulting from pressure of the gravid uterus on inferior vena cava and decreased venous tone

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4
Q

What are the most common inheritable causes of DVT in order of prevalence?

A
Factor V Leiden
Prothrombin G20210A variant
Protein C deficiency
Protein S deficiency
Antithrombin deficiency
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5
Q

What is factor V leiden disease?

A

Common inherited thrombophilia. Caused by a mutation in the factor V gene that causes resistance to protein C inactivation of factor V. Manifests clinically as increased likelihood of venous thromboembolism.

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