Thrombosis, Embolism and Pulmonary Hypertension Flashcards
What is the difference between a thrombus and a clot?
Thrombus- inside vessel
Clot- outside vessel
Where is thrombosis favoured according to Virchow’s triad?
Stasis (turbulent blood flow), endothelial injury and hypercoagulability
What can cause a hypercoagulable state?
Malignancy, pregnancy, hormone replacement, bowel disease, sepsis
What can cause endothelial injury?
Venous disorders, valve damage, trauma, surgery, catheters
What can cause stasis?
LV dysfunction, immobility, venous insufficiency/obstruction, pregnancy, obesity
What two things must happen for a thrombus to form?
Platelet activation and fibrin production
What does activating platelets do?
Makes them stickier so they aggregate more platelets and fibrin
What is the end point of the coagulation cascade?
Aggregation of fibrin
What is the first stage of thrombus formation?
Endothelial injury which exposes collagen
What happens in the formation of a thrombus after collagen has been exposed?
Collagen and Von Willebrand factor bind to glycoproteins on platelets which increases platelet integrins
What do glycoproteins on platelets bind with?
Fibrinogen
Describe the intrinsic coagulation pathway?
Hageman factor and Kallikrein through factors XII, IX, VIII
What is the extrinsic coagulation pathway?
Tissue factor binding with factor VII
What is the common pathway of coagulation?
Activated Factor IIa then through X, V, II
What happens after the common pathway of coagulation?
Factors II and XIII activate fibrinogen to fibrin
What type of vitamin is vitamin K and where is it stored?
Fat soluble in the liver
What does vitamin K produce?
Clotting factors II, VII, IX and X
What competes with vitamin K?
Warfarin
What is plasmin?
Clot buster
What are anti-clotting factors?
Protein S, protein C and antithrombin II
What causes inherited disorders of coagulibility?
Protein C/S/antithrombin II deficiency or Factor V Leiden
Why are thrombi less common in arteries?
High flow blood moves pro-coagulant material away quickly
When is the only occasion that thrombosis occurs in arteries?
Atherosclerosis
Why are sites where vessels branch more common?
More turbulent blood flow