Thrombosis Flashcards
What happens in thrombosis
Activation of platelets and clotting cascase
What happens in clotthng
Activation of protein cascade to get fibrin
What is virchows Triad
Promotes thrombosis
3 factors in Virchows triad
Changes in Surface of blood vessel
Changes in Blood flow
Changes in Blood constituents (Hypercoaguability)
3 ways the blood vessel can be altered
- Atheromatous plaque
- splitting/loss of the blood vessel surface layer
- exposure of the Sub-endothelial Tissue which activates platelets
Additionally how can inflammation damage the blood vessel
Vasculitis
What happens in DVT?
- Normal blood flow to legs
- Deep vein thrombosis occurs where there is activation of platelets and the clotting cascade.
- Inappropriate clotting leads to embolus.
- Embolus= unattached mass which breaks and travels up through blood stress
What is the hypercoaguable state
The Haemostatic equlibirum is shifted in favour of thrombosis
What changes in the blood ingredients do we get?
- More pro-coagulation factors (these can cause tumour)
- Changes in blood viscosity
- Decreased anti-coagulants
- increased platelets
Name risk factors to changes in blood flow
Smoking, Age, Obesity, OCP, Menopause + Diabetes
What are the 3 outcomes of the thrombus which is formed from the unnecessary clotting
- Lysis
- Embolus
- Organisation
What happens in embolisation
- A piece of Thrombi detach and travels in blood at high speed, it gets stuck in a vessel whos lumen is smaller than the size of the thrombi
Name different emboli
Thrombus, Infective, Gaseous,Fat, foreign material
What else can influence and alter blood flow
- Atril fibrilaition
- past MI
- congestive cardiac failure
