Thrombophillia

Question 1

how many types Thrombophillia

Answer 1

Congenital:
1- antithrombin 3 deficiency
2- Protein C 
3- Protein S
4- Factor 5 leiden

Acquired:
- Antiphopholipid syndrome

Question 2

3 categorization of congenital thrombophillia or clot formation

Answer 2

High risk: Antithrombin 3

Moderate risk: Protein C & S

Lowest risk: Factor 5 leiden

Question 3

the most common congenital thrrombophillia

Answer 3

factor 5 leiden (

Question 4

Factor 5 leiden 2 forms

Answer 4

heterozygous higher risk may be reaching moderate risk

Question 5

the least common congenital thrrombophillia

Answer 5

antithrombin 3

Question 6

clotting factors in pregnancy

Answer 6

Decrease in quality in pregnacy
1- antithrombin 3 deficiency
2- Protein C
3- Factor 5 leiden

Decrease in quantitiy
Protein S

Increase in pregnancy
Won willibrand factor
Fibrinogen
Ddimer

Question 7

The most common coagulation disorder in pregnancy

Answer 7

won willibrand disease

Question 8

Won willibrand disease
Incidence
genetic

Answer 8

1 %
autosomal dominant mainly
also autosomal recessive

Question 9

types of won willibrand disease

Answer 9

Type 1 : commonest , decrease quantitiy, Autosomal dominant
Type 2: decrease quality, AD
Type 3: Mixed with severe symptoms, severe, AR

Question 10

won willibrand disease type 1 ,
pregnancy effect
Complication

Answer 10

• improve significantly

- postdelivery severe drop, so PPH

Question 11

How to diagnose won willibrand disease

Answer 11

• Ristocetin (ris-to-SEE-tin) cofactor activity.

- Prolong APTT

Question 12

How to Treatment won willibrand disease

Answer 12

• Desmopressin
• Factor replacement or transplantation
• Tranxemic acid