Malaria in Pregnancy, Prevention

Question 1

Dosing regimen for chemoprophylaxis in pregnancy

Answer 1

Mefloquine:

• 1 tablet weekly 250mg,
• Chloroquine resistant (P. falciparum resistance)

Atovaquone-proguanila:

• 1 tablet daily
• 250mg, atovaquone + 100 proguanil
• Chloroquine resistant & mefloquine not tolerated or contraindicated OR Mefloquine resistant
• Folic acid supplements (5 mg daily) need to be taken if proguanil is used in those who are pregnant or seeking to become pregnant

Proguanila plus chloroquine:

• 2 tablets daily plus 2 tablets weekly
• 100 proguanil + 150 (chloroquine; base)
• No chloroquine resistance