Thromboembolic Disorders Flashcards
leading cause of maternal mortality
deep venous thrombosis
pulmonary embolism
the most constant predisposing factor for venous thrombosis
stasis
coagulation factors increased in pregnancy
fibrinogen
factor VII
factor VIII
von willebrand
the most important risk factor in developing thromboembolism
genetically determined thrombophilia
thrombin (IIa) acts in what coagulation cascade pathway?
intrinsic pathway
common pathway
the most thrombogenic of the heritable thrombophilia
antithrombin deficiency
antithrombin deficiency type that results in reduced synthesis of biologically normal antithrombin
type I deficiency
antithrombin deficiency type that is characterized by normal levels of antithrombin with reduced functional activity
type II deficiency
lethal antithrombin deficiency
homozygous antithrombin deficiency
treatment function of antithrombin
target towards the COMMON PATHWAY
treatment for antithrombin
low molecular weight heparin (LMWH)
recombinant human antithrombin concentration infusion
helps inactivates procoagulant Va and VIIa
protein S
vitamin K dependent glycoprotein that increases throughout the fist half of pregnancy
protein C
anticoagulant and inflammatory regulatory pathways
protein C
inhibits the synthesis of of PAI
activated protein c
activated protein c
thrombin + thrombomodulin
extensive thromboses in the micronutrition soon after birth leading to skin necrosis
purpura fulminans
activated protein c resistance aka
factor leiden mutation
most common heritable thrombophilia
heterozygous inheritance for factor V leiden
mutation in factor v gene; substitution of _________ for aginine at position 506
glutamine
second most inherited thrombophilia
prothrombin G20210A mutation (PGM)
mutation in prothrombin = excessive prothrombin accumulation
PGM
mutation of enzyme 5,10-methylene-tetrahydrofolate reductase
hyperhomocysteinemia
deficiencies of folic acid, vitamin b6, vitamin b12
hyperhomocysteinemia
