Connective Tissue Disorder

Question 1

CT disorder inherited disorder

Answer 1

marfan syndrome
osteogenesis imperfecta
ehlers-danlos syndrome

Question 2

low levels of fetal cells harboring a maternal blood and tissue cells – stimulate autoantibodies

Answer 2

fetal cell microchimerism

Question 3

overactive B lymphocytes responsible for autoantibody production

Answer 3

SLE

Question 4

specific test for SLE

Answer 4

anti-dsDNA/ anti-smith

Question 5

SLICC classification requirement

Answer 5

> or= 4 criteria (1 clinical, 1 laboratory)

Question 6

libman-sacks endocarditis commonly involves what valves

Answer 6

mitral and aortic valve

Question 7

what complicates pregnancy in woman with SL

Answer 7

chronic hypertension

Question 8

complication of preeclampsia

Answer 8

HELLP syndrome

Question 9

fetal cardiac involvement check which antibody?

Answer 9

anti-SS-A (anti-Ro)

Question 10

immunosuppressive drug for SLE

Answer 10

azathioprine 2-3mkd

Question 11

developed almost exclusively in fetuses of women with antibodies to the SS-A or SS-B antigens

Answer 11

congenital heat block

Question 12

chronic multisystem disease with unknown etiology

Answer 12

rheumatoid arthritis

Question 13

in RA infiltrating T cells will secrete

Answer 13

cytokines

Question 14

extraarticular manifestations of RA

Answer 14

rheumatoid nodules
vasculitis
pleuropulmonary symptoms

Question 15

pain relief treatment of RA

Answer 15

NSAIDs

Question 16

hallmark of systemic sclreosis

Answer 16

thickened or hardened skin

Question 17

hallmark of scleroderma

Answer 17

overproduction of normal collagen

Question 18

commonly affected GI in diffuse cutaneous systemic sclerosis

Answer 18

distal esophagus

Question 19

mixed connective tissue disease

Answer 19

overlap syndrome

Question 20

treatment for scleroderma renal crisis and interstitial lung disease

Answer 20

cyclophosphamide

Question 21

polyarteritis nodosa affects what type of arteries

Answer 21

small and medium sized arteries

Question 22

necrotizing granulomatous vasculitis of the upper and lower respiratory tract and kidney

Answer 22

wegener granulomatosis

Question 23

pulseless disease that affects the large vessels particularly the aorta

Answer 23

takayasu arteritis

Question 24

prominent blood eosinophilia vasculitides

Answer 24

churg-strauss vasculitis

Question 25

mutation in fibrinillin-1 gene; predispose to aortic dilation or dissecting aneurysm

Answer 25

marfan syndrome