Hematologic Complications

Question 1

common cause of pregnancy associated thrombocytopenia

Answer 1

gestational thrombocytopenia
severe preeclampsia
HELLP syndrome
DIC

Question 2

most common form of thrombocytopenia encountered in 3rd trimester

Answer 2

gestational thrombocytopenia

Question 3

immune thrombocytopeneic purpura is diagnosed through

Answer 3

ELISA or flow cytometry

Question 4

mainstay treatment of maternal thrombocytopenia

Answer 4

glucocorticoids

Question 5

in thrombocytopenia, no pharmacologic treatment is needed in the 1st and 2nd trimester unless the platelet count is?

Answer 5

<30,000/mm3

Question 6

enzyme deficient in TTP

Answer 6

ADAMTS13

Question 7

clinical syndrome characterized by progressive renal failure associated with microangiopathic hemolytic anemia and thrombocytopenia

Answer 7

hemolytic uremic syndrome

Question 8

primary pathology of HUS

Answer 8

progressive renal failure

Question 9

pentad of TTP

Answer 9

triad:
macroangiopathic hemolytic anemia
thrombocytopenia
neurologic abnormalities

fever
renal dysfunction

Question 10

TTP may mimic?

Answer 10

preeclampsia

Question 11

triad of HUS

Answer 11

microangiopathic hemolytic anemia
acute nephropathy
thrombocytopenia

Question 12

inital therapy for TTP and HUS

Answer 12

plasmapheresis

Question 13

mainstay treatment of HUS

Answer 13

supportive therapy

Question 14

common causes of anemia during pregnancy

Answer 14

physiologic anemia

IDA

Question 15

what indicates the total iron stores

Answer 15

serum ferritin level

Question 16

when should iron be taken?

Answer 16

30 mins before meals (TID)

Question 17

highest elemental iron content

Answer 17

ferrous fumarate - 107mg

Question 18

parenteral iron overdose can lead to?

Answer 18

hemosiderosis

Question 19

most common cause of megalobastic anemia

Answer 19

folate deficiency

Question 20

best test for folate deficency

Answer 20

serum folate

RBC folate

Question 21

recommended daily dose of folate to reduce neural tube defect

Answer 21

4mg

Question 22

4 prerequisites for cobalamin absorption

Answer 22

• presence of pepsin
• intrinsic factor (secreted by parietal cells)
• pancreatic protease
• intact ileum

Question 23

increased methylmalonate and homocysteine levels

Answer 23

vitamin B12 deficiency

Question 24

increased homocysteine level

Answer 24

folate deficiency

Question 25

substitution of valine for glutamic acid at the 6th position

Answer 25

hemoglobin s

Question 26

most common congenital bleeding disorder in humans

Answer 26

von willebrand disease