Hematologic Complications Flashcards
common cause of pregnancy associated thrombocytopenia
gestational thrombocytopenia
severe preeclampsia
HELLP syndrome
DIC
most common form of thrombocytopenia encountered in 3rd trimester
gestational thrombocytopenia
immune thrombocytopeneic purpura is diagnosed through
ELISA or flow cytometry
mainstay treatment of maternal thrombocytopenia
glucocorticoids
in thrombocytopenia, no pharmacologic treatment is needed in the 1st and 2nd trimester unless the platelet count is?
<30,000/mm3
enzyme deficient in TTP
ADAMTS13
clinical syndrome characterized by progressive renal failure associated with microangiopathic hemolytic anemia and thrombocytopenia
hemolytic uremic syndrome
primary pathology of HUS
progressive renal failure
pentad of TTP
triad:
macroangiopathic hemolytic anemia
thrombocytopenia
neurologic abnormalities
fever
renal dysfunction
TTP may mimic?
preeclampsia
triad of HUS
microangiopathic hemolytic anemia
acute nephropathy
thrombocytopenia
inital therapy for TTP and HUS
plasmapheresis
mainstay treatment of HUS
supportive therapy
common causes of anemia during pregnancy
physiologic anemia
IDA
what indicates the total iron stores
serum ferritin level
when should iron be taken?
30 mins before meals (TID)
highest elemental iron content
ferrous fumarate - 107mg
parenteral iron overdose can lead to?
hemosiderosis
most common cause of megalobastic anemia
folate deficiency
best test for folate deficency
serum folate
RBC folate
recommended daily dose of folate to reduce neural tube defect
4mg
4 prerequisites for cobalamin absorption
- presence of pepsin
- intrinsic factor (secreted by parietal cells)
- pancreatic protease
- intact ileum
increased methylmalonate and homocysteine levels
vitamin B12 deficiency
increased homocysteine level
folate deficiency
