Thrombocytopenia: class 3 Flashcards
0
Q
Platelet
-Action
A
- Adhere to the wall of an injured vessel
1
Q
Platelets
A
- Formed by bone marrow as megakaryocytes
- Survive 8-10 days
- Only fragments of cytoplasm (not cells)
- Produced in bone marrow
- Stored in spleen and removed by the speen
2
Q
Thrombocytosis
A
- Excess of platelets (over 450,000)
3
Q
Thrombocytopenia
A
- PLT count < 150,000
4
Q
Anticoagulants
A
- Decrease platelet aggregation
2. Prevent further clots from forming
5
Q
Fibrinolytics
A
- Lyse clots that have formed and prevent clotting
6
Q
Hemostasis (clotting)
-process
A
- Thromboxane A2 released when vessel spasms and vessel constricts
- Formation of platelet plug
- platelets attach to vessel wall and each other
- fibrin holds plug together
7
Q
Prothrombin Time (PT) & INR -Normal values
A
- PT : 10-12 seconds
2. INR: 0.8-1.2
8
Q
Therapeutic INR
-Value?
A
- 2.5
9
Q
Activated partial thromboplastin time (aPTT)
-Normal levels
A
- 30-40 seconds
10
Q
Activated partial thromboplastin time (aPTT)
-Therapeutic Levels
A
- 1.5-2.5 X normal
11
Q
PT & INR
-What drug? What antidote?
A
- Warfarin (coumadin)
2. Antidote is Vitamin K
12
Q
aPTT
-What Drug? What antidote?
A
- Heparin
2. Protamein Sulfate
13
Q
Thrombocytopenia
-considerations
A
- PLT count < 150,000
- <10,000
- Spontaneous bleeding (rarely can cause intracranial bleed)
14
Q
Petechiae & Purpura
A
- Petechiae are the small dots of blood
2. Purpura are the larger bruises