Thomas

Question 1

binds to beta-tubulin subunit of tubulin and blocks DISSASEMBLY of microtubule bundles. Treats esophageal cancer

Answer 1

Paclitaxel and Doxitaxel

Question 2

Major Contraindication for Gemcitabine

Answer 2

radiation therapy

Question 3

First choice agent for metastatic pancreatic cancer; Also for esophageal cancer. Active against dividing and non-dividing cells.

Answer 3

Gemcitabine

Question 4

Oral prodrug for 5FU

Answer 4

Capecitabine

Question 5

Blocks thymidilate synthase .:. prevents production of thymidine

Answer 5

5FU (.:. Capecitabine also)

Question 6

Give 5FU with

Answer 6

Leucovorin and Methotrexate, Oxaliplatin, or irinotecan

Question 7

Orally active reversible inhibitor of EGFR - tyrosine kinase.

Answer 7

Erlotinib

Question 8

chimeric mab that binds to EGFR AND has Ab dependent cellular cyotoxicity

Answer 8

Cetuximab

Question 9

Humanized mab that blocks binding of EGFR

Answer 9

Panitumumab

Question 10

It’s a trap!

Answer 10

Bevacizumab

Question 11

humanized mab against VEGF; Use with FolFIri

Answer 11

Bevacizumab

Question 12

Activated by water
alkylator of guanines
MAJOR N/V
Resistance: Mutated mismatch repair

Answer 12

Cisplatin

Question 13

Resistance to Cisplatin

Answer 13

1 - over expression of glutathione
2 - Overactive NT excision repair
3 - mutated MMR

Question 14

oxaliplatin is for treatment of

Answer 14

colon cancer

Question 15

Oxaliplatin is not susceptible to what mechanism of resistance

Answer 15

mutated MMR

Question 16

Indication For Streptozocin

Answer 16

treatment of pancreatic carcinoma, stomach, and small intestine

Question 17

Why is Streptozocin good for pancreatic carcinoma?

Answer 17

glucose binds to islets of langerhans

Question 18

Which is less toxic: streptozocin or carmustine?

Answer 18

streptozocin

Question 19

tricyclic glycopeptide that binds to D-Ala-D-Ala precursor to inhibit transglycosylase. Administered IV only. Poorly absorbed orally

Answer 19

Vancomycin

Question 20

tricyclic glycopeptid. Administered IM and IV. Poorly absorbed orally.

Answer 20

Teicoplanin

Question 21

polypeptide that inhibits bacterial cell wall synthesis. Used topically in dermatologic and ophthalmic ointments. It interferes with the dephosphorylation of a lipid transport molecule, which carries the building blocks of the peptidoglycan bacterial cell wall. Not absorbed orally

Answer 21

bacitracin

Question 22

Which lasts longer: vancomycin or teicoplanin?

Answer 22

teicoplanin

Question 23

What allows an antibiotic to be oral?

Answer 23

ether group - confers H+ resistance

Question 24

most popular 2nd generation oral cephalosporin

Answer 24

cefaclor

Question 25

Only 3rd gen oral cephalosporin

Answer 25

cefpodoxime

Question 26

Problem with dairy, antacids and tetracyclines

Answer 26

chelation = less absorption

Question 27

Which antibiotic group stay in the system for weeks and why?

Answer 27

tetracyclines; Enterohepatic circulation and bile

Question 28

Major tetracycline tox

Answer 28

nepherotox

Question 29

glycycline, which is a butyl-glycylamido derivative of the tetracycline, minocycline. It is not absorbed orally. Parenteral use only with rapid and wide distribution into tissues. Effective against tetracycline-resistant bacteria.

Answer 29

tigecycline

Question 30

Benefits of tigecycline over tetracyclines (2)

Answer 30

1 - less affinity for efflux pumps | 2 - less nepherotox

Question 31

can be administered orally as the active drug. It affects the hematopoietic system in two ways: a dose-related toxicity that presents as anemia, leukopenia, or thrombocytopenia; and an idiosyncratic response manifested by aplastic anemia, leading in many cases to fatal pancytopenia. Fetuses and young children cannot glucuronidate the drug causing gray baby syndrome.

Answer 31

Chloramphenicol

Question 32

Gray baby syndrome

Answer 32

Chloramphenicol

Question 33

When do you use Chloramphenicol

Answer 33

preggo with Rocky Mountain Spotted Fever | 3rd world meningitis

Question 34

antibiotic class that causes crystaluria

Answer 34

sulfonamides

Question 35

MOA of sulfonamides

Answer 35

inhibits production of folate, which is made by bacteria and not ppl

Question 36

sulfonamide that can be used solo

Answer 36

sulfisoxazole

Question 37

benefit of sulfisoxazole

Answer 37

v. soluble .:. no crystaluria

Question 38

Bactrim is made of (2)

Answer 38

sulfamethoxazole - trimethaprim

Question 39

Tx of Nontyphoid salmonella

Answer 39

ciprofloxin levofloxin (For Typhoid: cipro or cetriaxone)

Question 40

Typhoid fever tx

Answer 40

Ciprofloxin ceftriaxone (For non-typhoid: fluoroquinolones)

Question 41

Shigella tx

Answer 41

Ciprofloxin Levoquin TMX-sulfa

Question 42

C. jejuni tx

Answer 42

Azithromycin | Cipro

Question 43

E. coli tx

Answer 43

Ciprofloxin | Levofloxin

Question 44

Yersinia tx

Answer 44

Doxycyclin + gentamycin

Question 45

C. Difficile (moderate) tx

Answer 45

Metronidazole | 2ndary is Nitazoxanide

Question 46

C. dif (severe) tx

Answer 46

vancomycin

Question 47

in TMX-Sulfa, where does tox come from?

Answer 47

sulfamethoxazole

Question 48

If in doubt, for severe diarrhea, give

Answer 48

Cipro or Levafloxin

Question 49

not a macrolide, but binds 50S and inhibits translocation step

Answer 49

clindamycin

Question 50

ketolide that is less susceptible to methylase-mediated and efflux-mediated resistance than macrolides like erythromycin or clarithromycin

Answer 50

Telithromycin

Question 51

Giardia tx

Answer 51

Metronidazole Tinidazole paramomycin

Question 52

Entamoeba tx

Answer 52

Metronidazole Tinidazole paramomycin iodoquinol

Question 53

Cryptosporidium tx

Answer 53

Nitazoxanide | stops PFOR rxn

Question 54

Same MOA as metronidazole, but less GI tox

Answer 54

tinidazole

Question 55

interferes with the ferredoxin oxidoreductase (PFOR) enzyme-dependent electron-transfer reaction, which is essential in anaerobic metabolism. No resistance, little toxicity.

Answer 55

Nitazoxanide | For cryptosporidium

Question 56

Nematodes tx

Answer 56

(Round Worms) Benzimidazoles Ivermectin

Question 57

Hookworms tx

Answer 57

Benzimidazoles | Ivermectin

Question 58

Trematodes tx

Answer 58

(Flukes) Praziquantel Metrifonate

Question 59

Cestodes tx

Answer 59

(Tape Worms) | Praziquantel

Question 60

In parasites, inhibit microtubule polymerization by binding to parasite beta tubulin; not toxic

Answer 60

Benzimidazoles | for nematodes

Question 61

In parasites, causes influx of Ca to produce paralysis of the musculature. Toxcity: dose-related transient abdominal distress.

Answer 61

Praziquantel | For cestodes and trematodes

Question 62

In parasites, tonic paralysis of the worm musculature by activating glutamate-gated Cl channels and is well tolerated.

Answer 62

Ivermectin | for nematodes

Question 63

In parasites, organophosphate converted to dichlorvos, a cholinesterase inhibitor.

Answer 63

Metrofinate

Question 64

Which of these is for HBV: Adefovir Oseltamivir Zidovudine

Answer 64

Adefovir

Question 65

Which of these is for HBV: Fomivirsen Lamivudine Nelfinavir

Answer 65

Fomivirsen

Question 66

Which of these is for HBV: Maraviroc Tenefovir Zanamivir

Answer 66

Tenefovir

Question 67

Which of these is for HBV: Entecavir Lopinavir Vivecon

Answer 67

Entecavir

Question 68

Which of these is for HBV: Amantadine Bevirimat Telbivudine

Answer 68

Telbivudine

Question 69

Indication for IFN alpha and ribavirin

Answer 69

HCV

Question 70

What is VEGF?

Answer 70

Vascular endothelial growth factor

Question 71

What is EGFR?

Answer 71

epidermal growth factor receptor

Question 72

Name 3 drugs that stop the action of EGFR

Answer 72

Erlotinib (oral, via EGFR-TK) Cetuximab Panitumumab