Misc GI

Question 1

Glucocorticoid with low oral availability used for IBD

Answer 1

Budesonide

Question 2

Treat severe colitis from C. difficile (2)

Answer 2

Vancomycin; Teicoplanin

Question 3

Antibiotic that prevents tRNA binding to 30S; Treats Yersinea enterocolitica.

Answer 3

Tetracyclines (ex. doxy and mino)

Question 4

Resistance to Tetracycline (3)

Answer 4

1- influx/efflux; 2 -binding site mutation; 3 - inactivation

Question 5

SE to Tetracycline (4)

Answer 5

GI tox
photosensitivity
brown teeth during development
nepherotox (except doxy)

Question 6

Why is Doxycyline not nepherotoxic?

Answer 6

fecal excretion

Question 7

For Colon Cancer; activated by water –> crosslinks DNA by binding guanines .:. prevent replication. Attracts HMG-1 which become irreversibly bound. Ineffective repair –>apoptosis

Answer 7

Cisplatin

Question 8

Resistance for Cisplatin (2)

Answer 8

1 - increased NT excision repair protein

2 - LOF in mismatch repair (HMG1

Question 9

Cisplatin Tox (3)

Answer 9

Nephero
Oto
Nausea/Vomiting

Question 10

Antiprotazoal; Treats Cryptosporidium. No resistance and few SE

Answer 10

nitazoxamide

Question 11

What drug interferes with feredoxin oxidoreductase (PFOR)?

Answer 11

Nitoazoxamide

Question 12

Prodrug that becomes 6-mercaptopurine

Answer 12

azathioprine

Question 13

Drug activated by HGPRT (hypozanthine-guanine phosphoribosyltransferase)

Answer 13

6-MP

Question 14

Which has greater bioavailability: Azathioprine or 6MP?

Answer 14

Azathioprine

Question 15

For treatment of IBD, but takes 17 weeks for therapeutic benefic

Answer 15

Azathioprine and 6MP

Question 16

Tox of Azathioprine and 6MP (5)

Answer 16

inhibits rapidly dividing cells (epithelial)
N/V
Bone marrow depression
Hepatic Tox
Teratogen

Question 17

Antihelminth that opens nonselective cation channels .:. activate nicitinic AchR .:. spastic paralysis of worm

Answer 17

Pyrantel Pamoate

Question 18

Pyrantel Pamoate Tox

Answer 18

neuromuscular blockade

Question 19

Treats Entamoeba

MOA: chelates ferous ions essential for metabolism.

Answer 19

Iodoquinol

Question 20

Iodoquinol tox

Answer 20

Not absorbed, so few SE

Question 21

fully human MAB to TNF alpha

Answer 21

Adalimumab

Question 22

chimeric MABs to TNF alpha

Answer 22

Infliximab

Certolizumab

Question 23

Indications for Infliximab? Certolizumab? Adalimimab?

Answer 23

Crohn’s for all

Also Ulcerative cholitis for Infliximab

Question 24

Tox for Infliximab? Certolizumab? Adalimimab?

Answer 24

TH1 suppression .:. increased risk infection (PPD prior)
Ab production –> hypersensitivity; serum-sickness
Hepatic failure

Question 25

EGFR-tyrosine kinase reversible inhibitor for treatment of colon cancer

Answer 25

erlotinib

Question 26

Use erlotinib with

Answer 26

FOLFOX

Question 27

MOA of Erlotinib

Answer 27

EGFR-tyrosine kinase reversible inhibitor –> blocks EGFR autophosphorylation and signal transduction .:. decrease prolif/angiogenesis/metastasis and increase apoptosis

Question 28

Erlotinib tox

Answer 28

diarrhea

rash

Question 29

Resistance to Vancomycin

Answer 29

alteration of D-ala-D-ala

Question 30

Treatment of Salmonella, Shigella, Campylobacter, E. Coli bacteria

Answer 30

(Fluoroquinolones)
Ciprofloxin
Levofloxin

Question 31

Resistance to Fluoroquinolones

Answer 31

DNA Gyrase mutation

Question 32

Fluoroquinolone Tox (2)

Answer 32

Arthritis in children

GI distress

Question 33

Fluoroquinolone C/I

Answer 33

children

Question 34

Drug MOA: inhibit DNA gyrase and Topo IV

Answer 34

Fluoroquinolones

Question 35

Binds 50S peptidyltransferase to block translocation

Answer 35

Clindamycin

Question 36

Antiviral for HCV

Answer 36

Ribavirin

Question 37

Ribavirin MOA

Answer 37

inhibits viral mRNA synthesis

Question 38

use Ribavirin in combo with

Answer 38

IFNalpha