Misc GI Flashcards

1
Q

Glucocorticoid with low oral availability used for IBD

A

Budesonide

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2
Q

Treat severe colitis from C. difficile (2)

A

Vancomycin; Teicoplanin

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3
Q

Antibiotic that prevents tRNA binding to 30S; Treats Yersinea enterocolitica.

A

Tetracyclines (ex. doxy and mino)

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4
Q

Resistance to Tetracycline (3)

A

1- influx/efflux; 2 -binding site mutation; 3 - inactivation

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5
Q

SE to Tetracycline (4)

A

GI tox
photosensitivity
brown teeth during development
nepherotox (except doxy)

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6
Q

Why is Doxycyline not nepherotoxic?

A

fecal excretion

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7
Q

For Colon Cancer; activated by water –> crosslinks DNA by binding guanines .:. prevent replication. Attracts HMG-1 which become irreversibly bound. Ineffective repair –>apoptosis

A

Cisplatin

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8
Q

Resistance for Cisplatin (2)

A

1 - increased NT excision repair protein

2 - LOF in mismatch repair (HMG1

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9
Q

Cisplatin Tox (3)

A

Nephero
Oto
Nausea/Vomiting

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10
Q

Antiprotazoal; Treats Cryptosporidium. No resistance and few SE

A

nitazoxamide

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11
Q

What drug interferes with feredoxin oxidoreductase (PFOR)?

A

Nitoazoxamide

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12
Q

Prodrug that becomes 6-mercaptopurine

A

azathioprine

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13
Q

Drug activated by HGPRT (hypozanthine-guanine phosphoribosyltransferase)

A

6-MP

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14
Q

Which has greater bioavailability: Azathioprine or 6MP?

A

Azathioprine

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15
Q

For treatment of IBD, but takes 17 weeks for therapeutic benefic

A

Azathioprine and 6MP

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16
Q

Tox of Azathioprine and 6MP (5)

A
inhibits rapidly dividing cells (epithelial)
N/V
Bone marrow depression
Hepatic Tox
Teratogen
17
Q

Antihelminth that opens nonselective cation channels .:. activate nicitinic AchR .:. spastic paralysis of worm

A

Pyrantel Pamoate

18
Q

Pyrantel Pamoate Tox

A

neuromuscular blockade

19
Q

Treats Entamoeba

MOA: chelates ferous ions essential for metabolism.

A

Iodoquinol

20
Q

Iodoquinol tox

A

Not absorbed, so few SE

21
Q

fully human MAB to TNF alpha

A

Adalimumab

22
Q

chimeric MABs to TNF alpha

A

Infliximab

Certolizumab

23
Q

Indications for Infliximab? Certolizumab? Adalimimab?

A

Crohn’s for all

Also Ulcerative cholitis for Infliximab

24
Q

Tox for Infliximab? Certolizumab? Adalimimab?

A

TH1 suppression .:. increased risk infection (PPD prior)
Ab production –> hypersensitivity; serum-sickness
Hepatic failure

25
EGFR-tyrosine kinase reversible inhibitor for treatment of colon cancer
erlotinib
26
Use erlotinib with
FOLFOX
27
MOA of Erlotinib
EGFR-tyrosine kinase reversible inhibitor --> blocks EGFR autophosphorylation and signal transduction .:. decrease prolif/angiogenesis/metastasis and increase apoptosis
28
Erlotinib tox
diarrhea | rash
29
Resistance to Vancomycin
alteration of D-ala-D-ala
30
Treatment of Salmonella, Shigella, Campylobacter, E. Coli bacteria
(Fluoroquinolones) Ciprofloxin Levofloxin
31
Resistance to Fluoroquinolones
DNA Gyrase mutation
32
Fluoroquinolone Tox (2)
Arthritis in children | GI distress
33
Fluoroquinolone C/I
children
34
Drug MOA: inhibit DNA gyrase and Topo IV
Fluoroquinolones
35
Binds 50S peptidyltransferase to block translocation
Clindamycin
36
Antiviral for HCV
Ribavirin
37
Ribavirin MOA
inhibits viral mRNA synthesis
38
use Ribavirin in combo with
IFNalpha