THIRD QUIZ Flashcards
non-specific serum components; to enhance the effect of ABS
complements
innate immunity composed of
PHYSICAL COMPONENT –SKIN
BIOLOGICAL COMPONENT- SWEAT (ACIDIC)
CHEMICAL COMPONENT
cellular components of cell immunity
cellular - tcells
humoral - non-cellular
most important function of internal defense system;o they engulf and destroy most pathogen that enter the body via pathogen recognition receptor
phagocytosis
tool like receptor;food in pathogen
pumps
Although the receptor have specific for each microorganism, it has similarities. They all have the same component called _____
LEUCINE RICH REPEATS
most important cells involved in pathogen recognition receptor
dendritic cell and macrophages
Protein;capable of degrading some of the components of bacteria exposing the internal structure of bacteria
lysozyme
bacterial and virucidial;presence of C3 and Mg
properdin
heat stable;cationic found in serum; bactericial activity
beta-lysin
host specific antiviral activity and glycoprotein; INTERFERE THE ACTIVITY OF THE VIRUSES TO REPRODUCE
INTERFERON
modulates;capable of activate and inactivate
immunomodulators
anti-cancer capability
antineoplastic
early innate immuno response to viral infection;class I
type I IFNs
produce by the WBC called LEUKOCYTES INTERFERENCE
IFNa
seen in epithelial tissue and fibroblast
IFNb
major macrophage activator; MH class I and class II;antagonist to IL-4
Type II IFNs
produced by t helper and cell;also called IMMUNE INTERFERON
GAMMA INTERFERON
Principal mediator of the host response to GRAM (-) bacteria; stimulates neutrophils and monocytes
TUMOR NECROSIS FACTOR (TNF)
produced by T and B lymphocytes; killing;endothelial activation; LYMPHOTOXIN –> also called
TNF-b
local inflammation; endothelial activation; also called–> CACHETIC; produced by cancer cell; produced by macrophage and NK cells
TFN-a
local inflammation; endothelial activation; also called–> CACHETIC; produced by cancer cell; produced by macrophage and NK cells
TFN-a
important in differentiation and activation of cell
interleukins
fever
IL-1
T CELL STIMULATOR’GROWTH FACTOR
IL-2
STIMULATION IN THE BONE MARROW’ MULTICOLONY STIMULATING FACTOR
IL-3
SECRETION OF IgE FROM B CELL
IL-4
ACTIVATION OF EOSINOPHILS; IgA
IL-5
SYNTHESIS OF ACUTE PHASE PROTEIN
IL-6
LYMPHOID LINEAGE
IL-7
NEUTROPHILS/CHEMTAXIN
IL-8
PARASITES
IL-9
has the capacity to secrete IL4,IL5,IL10
ILA-NAIVE T CELL
activate TH2
IL-4
produced Type II interform
NK cell and T helper cell
inflammation markers that exhibit significant changes in serum concentration during inflammation
ACUTE PHASE REACTANTS
prominent systemic reaction of the organism to local or systemic disturbances in its homeostasis
ACUTE PHASE RESPONSE
ACUTE PHASE REACTANTS HAS 2
POSITIVE ACUTE PHASE REACTANTS
NEGATIVE ACUTE PHASE REACTANTS
most widely used indicator of Acute Inflammation; nonspecific but highly sensitive
Considered as the direct measure of the inflammatory response
CRP (C-REACTIVE PROTEIN)
influence HDL cholesterol transport
SERUM AMYLOID A
master regulator of systemic iron homeostasis
HEPCIDIN
antioxidant, antimicrobial, and anti-inflammatory properties
HAPTOGLOBIN
sequesters iron to inhibit microbial iron scavenging
FERRETIN
promote endothelial repair - also has a C3 complement function
Correlates with ESR
FIBRINOGEN
sensitive marker for following the progression of infections, especially for pneumonia and sepsis.
Levels of this can be used to guide antibiotic therapy
PROCALCITONIN
histaminase-and ferroxidase-activity
CERULOPLASMIN
serine protease inhibitor (serpin) that breaks down neutrophil elastase
protects the cells against neutrophil elastase activity
ALPHA-1 ATITRYPSIN (AAT)
Macrophages internalize transferrin to sequester iron and inhibit microbial iron scavenging
TRANSFERRIN
production is decreased to conserve amino acids for positive APPs
ALBUMIN
body’s overall reaction to injury or invasion by an infectious agent
inflammation
