SECOND QUIZ Flashcards
substance that reacts with an antibody or sensitized T cells
but may not be able to evoke an immune response in the first
place
ANTIGENS
evoke an immune response
NON SELF ANTIGEN/IMMUNOGENS
we have developed
immune response against our own antigen, results into disorder
AUTOIMMUNE DISORDER
All immunogens are all antigens but not all antigens are
immunogens
Ability of an immunogen to stimulate a host response; How effective the ability of immunogen to elicit an immune
response
IMMUNOGENICITY
GENERAL RULE
THE HIGHER THE MOLECULAR WEIGHT, THE MORE IMMUNOGENIC
most of the time
the ones who are immunogenic has molecular weight of _____
100,000 DALTONS
FACTORS THAT AFFECT IMMUNOGENICITY
1.MACROMOLECULAR SIZE
2. FOREIGNNESS
3. CHEMICAL COMPOSITION AND MOLECULAR COMPLEXITY
4. THE ABILITY TO BE PROCESSED AND PRESENTED WITH MHC MOLECULES
the role of this factor is “the higher the molecular weight, the more immunogenic”
macromolecular size
There are immunogens that are small when it comes with their
molecular weight but more immunogenic than high molecular
weight
micromolecular size
How foreign the antigen to our self-antigen; comparison to self
antigen
The more distant taxonomically the source of immunogen is
from the host, the more successful it is as a stimulus
foreignness
most immunogenic;
PROTEIN
most immunogenic among macromolecules
proteins and polysaccharides
less immunogenic
carbohydrates
not immunogenic
nucleic acid and lipid
How effective to be processed by antigen presenting cells
(APCs)
Most important factor for a substance to elicit an immune
response, it must be subjected to antigen processing via APCs.
NEED TO BE PROCCESED; IF NOT NOIMMUNIGENS;MUST BE IN CELL
ABILITY TO BE PROCESSED AND PRESENTED IN MHC MOLECULES
Substance administered with an immunogen that increases the
immune response in order to provide immunity to a particular
disease.;To strengthen immunogenicity of immunogen to elicit immune
response; EXAMPLE: VACCINE
ADJUVANT
2 types of adjuvant:
epitope - exact antigen binding site
paratope - exact antibody binding site
Self-antigen the belongs to the host
AUTOANTIGEN
Antigens from family of the same species, but capable of
eliciting immune response to you.
ALLOANTIGEN
Antigens from a different specie like animals, plants,
microorganism; same structure with humans; capable of cross immunity
HETEROANTIGEN
found in unrelated plant and animals cross react with other antibodies
HETEROPHILANTIGEN
genes are found on short
arm of the chromosomes
HUMAN LEUKOCYTE ANTIGEN
MHC CLASS 1
LOCUS A, LOCUS B, LOCUS C
Highest express of MHC class I are found on ______
LYMPHOCYTES AND MYELOID CELL
Lowest concentration
LOCUS C
significant on HLA typing
LOCUS A AND LOCUS B
MHC Class II
DP GENE, DQ GENE, DR GENE
______highest expression on MHC class II
because they are the most effective antigen presenting cell.
DENDRITIC CELL
all nucleated cells contain surface protein
(antigen) that elicit immune response
MHC CLASS III
FUNCTION OF CLASS I:present endogenous antigen to
cytotoxic T lymphocytes
FUNCTION OF CLASS II: To present exogenous antigen to T helper
lymphocytes
FUNCTION OF CLASS I:present endogenous antigen to
cytotoxic T lymphocytes
FUNCTION OF CLASS II: To present exogenous antigen to T helper
lymphocytes
