SECOND QUIZ Flashcards
substance that reacts with an antibody or sensitized T cells
but may not be able to evoke an immune response in the first
place
ANTIGENS
evoke an immune response
NON SELF ANTIGEN/IMMUNOGENS
we have developed
immune response against our own antigen, results into disorder
AUTOIMMUNE DISORDER
All immunogens are all antigens but not all antigens are
immunogens
Ability of an immunogen to stimulate a host response; How effective the ability of immunogen to elicit an immune
response
IMMUNOGENICITY
GENERAL RULE
THE HIGHER THE MOLECULAR WEIGHT, THE MORE IMMUNOGENIC
most of the time
the ones who are immunogenic has molecular weight of _____
100,000 DALTONS
FACTORS THAT AFFECT IMMUNOGENICITY
1.MACROMOLECULAR SIZE
2. FOREIGNNESS
3. CHEMICAL COMPOSITION AND MOLECULAR COMPLEXITY
4. THE ABILITY TO BE PROCESSED AND PRESENTED WITH MHC MOLECULES
the role of this factor is “the higher the molecular weight, the more immunogenic”
macromolecular size
There are immunogens that are small when it comes with their
molecular weight but more immunogenic than high molecular
weight
micromolecular size
How foreign the antigen to our self-antigen; comparison to self
antigen
The more distant taxonomically the source of immunogen is
from the host, the more successful it is as a stimulus
foreignness
most immunogenic;
PROTEIN
most immunogenic among macromolecules
proteins and polysaccharides
less immunogenic
carbohydrates
not immunogenic
nucleic acid and lipid
