Third Line of Defense and Nature or Antigens Flashcards
Cellular Components
o T Lymphocyte
o B Lymphocytes
o Plasma cells
Humoral Components
Antibodies
Cytokines
Humoral-Mediated
Immunity Mechanism
Antibody mediated
Cell-Mediated
Immunity Mechanism
Cell mediated
Humoral-Mediated
Immunity Cell Types
B lymphocytes
Cell-Mediated
Immunity Cell Types
T lymphocytes
Humoral-Mediated
Immunity Mode of Action
Antibodies in serum
Cell-Mediated
Immunity Mode of Action
Direct cell-to-cell contact or soluble products secreted (such as cytokines) by cells
Humoral-Mediated
Immunity Purpose
Primary defense against bacterial infection
Cell-Mediated
Immunity Purpose
Defense against viral and fungal infections, intracellular organisms
(parasites- malaria, babesia), tumor
antigens, and graft rejection.
Have barriers, phagocytes, dendritic cells, plasma cells (complement), and NK cells
Innate
these are the lymphocytes that did not yet encounter an antigen
Naive B and T cells-
Upon encountering an antigen, they will
bind to the antigen and they will form antibodies
Naive B cell
Once they will
encounter an antigen, they will become an effector T
cell.
Naive T cell
o will produce antibodies and recognize via membranebound antibodies.
o It can also recognize different chemical structures of different antibodies (proteins, lipids or
polysaccharides)
o Will depend on the type of antigen that is being encountered
B cells
The _____________ when stimulated by antigens, will
become plasma cells and then they will secrete large
number of antibodies after response.
The Naive B cells when stimulated by antigens, will
become plasma cells and then they will secrete large
number of antibodies after response.
________________ will remember the particular antigen, upon exposure, the response now will be faster
Memory B cells will remember the particular antigen, upon exposure, the response now will be faster
they can only recognize peptide fragments that are presented by APCs (Antigen
Presenting Cell
T cells
will present the antigen to the T cells) via molecules known as MHC (_________________________) that is present on the
surface of the APC
APCs (Antigen
Presenting Cell
MHC (Major
Histocompatibility Complex)
Upon presentation of the APC on a specific antigen that found on the MHC, the Naive T cell will become
stimulated and will be able to proliferate into two subsets:??
CD4 (T Helper cell)
CD8 (Cytotoxic T Cell)
secrete soluble molecules which will help the B cells to produce antibodies and activate macrophages
CD4 (T Helper cell)
secrete soluble mediators that will play an important
role in killing virus, infection, and tumor cells.
CD8 (Cytotoxic T Cell)
After response, __________________ will also persist remember the particular antigen. Same concept with regard to the _______________ when it comes to viruses and upon re-exposure again to the particular virus. It will remember it ______ and the reaction of the immune system will also become ______. Thus, the elimination of the antigen is ______.
CD8 (Cytotoxic T Cell)
After response, T memory cells will also persist remember the particular antigen. Same concept with regard to the memory B cells when it comes to viruses and upon re-exposure again to the particular virus. It will remember it faster and the reaction of the immune system will also become faster. Thus, the elimination of the antigen is faster.
ACTIVE IMMUNITY or PASSIVE IMMUNITY
Host: responsible for
producing the immune
response/ antibodies
ACTIVE IMMUNITY
