Thiazolidinediones

Question 1

What is the brand name of pioglitazone?

Answer 1

Brand = Actos

Question 2

What is the brand name of rosiglitazone?

Answer 2

Brand = Avandia

Question 3

What is the MOA of rosiglitazone and pioglitazone?

Answer 3

It decreases insulin resistance in the adipose and muscle tissue
It decreases gluconeogenesis in the liver
It binds to the PPAR-gamma = a transcription factor –> leading to an increase in insulin receptor binding AND increase in GLUT 1 & 4 transporters for glucose to transport in adipose and muscle tissue

Question 4

Can TZDs increase weight?

Answer 4

Yes, there’s a possibility

Question 5

What is the initial dose for pioglitazone?

Answer 5

Initially: 15-30 mg/day

Question 6

What is the initial dose for rosiglitazone?

Answer 6

Initially: 2-4 mg/day

Question 7

What are the 3 main contraindications for TZDs?

Answer 7

1. Hepatic insufficiency
2. HF (even if suspected)
3. Severe edema

Question 8

What are the 3 main adverse effects for TZDs?

Answer 8

1. Hepatic insufficiency
2. Weight gain
3. Edema

Question 9

Does TZDs affect fasting glucose, postprandial glucose, or both?

Answer 9

Only fasting glucose