SGLT-2 inhibitors Flashcards
What is the brand name of empagliflozin?
Brand: Jardiance
What is the brand name of dapagliflozin?
Brand: Farxiga
What is the brand name of canagliflozin?
Brand: Invokana
What is the MOA for dapagliflozin, empagliflozin, and canagliflozin?
It inhibits the SGLT-2 cotransporter in the PCT of the kidneys preventing glucose to be reabsorbed back into the systemic circulation
Is the MOA for SGLT-2i’s a glucose-dependent effect, or no?
Yes
Does SGLT-2i’s effect fasting glucose, postprandial glucose, or both?
BOTH
fasting and postprandial glucose
What is the initial dosing for canagliflozin?
Initial = 100 mg/day Max = 300 mg/day
What is the initial dosing for dapagliflozin?
Initial = 5 mg/day Max = 10 mg/day
What is the initial dosing for empagliflozin?
Initial = 10 mg/day Max = 25 mg/day
Can canagliflozin be recommended for a patient with a GFR of 30-60 mL/min/1.73 m^2?
Yes
Max dose = 100 mg
Can canagliflozin be recommended for a patient with a GFR < 30 mL/min/1.73 m^2?
NO
Can dapagliflozin be recommended in a patient with a GFR < 25 mL/min/1.73 m^2?
NO
Can empagliflozin be recommended in patients with a GFR < 30 mL/min/1.73 m^2?
NO
Can empagliflozin be recommended in patients to treat HF w/ a GFR < 20 mL/min/1.73 m^2?
NO
What are 4 contraindications for SGLT-2i’s?
- Ketoacidosis (do not decrease dose too quickly)
- Hyperkalemia
- Hypoglycemia (could occur especially w/ sulfonylureas or insulin)
- ESRD/dialysis
