THIAZIDE AND THIAZIDE LIKE DIURETICS

Question 1

what does thiazide diuretics inhibit

Answer 1

Na and Cl

Question 2

where does thiazide diuretic work

Answer 2

distal convoluted tubule

Question 3

generic name is hydrochlorothiazide- name the route of administration

Answer 3

brand is hydrodiuril - PO

Question 4

generic name is chlorothiazide name the route of administration

Answer 4

brand name is diuril - PO/IV

Question 5

generic name is chlorthalidone - name the route of administration

Answer 5

brand name is hygroton - PO

Question 6

generic name is indapamide - name the route of administration

Answer 6

brand name is lozol - PO

Question 7

generic name is metolazone -name the route of administration

Answer 7

brand name is zaroxolyn - PO

Question 8

thiazide diuretics uses

Answer 8

• hypertension = monotherapy or with ACE- inhibitor
• edema associated states aka CHF/ hepatic cirrhosis/ nephrotic syndrome/ chronic renal failure

Question 9

thiazide diuretic contraindications

Answer 9

• sulfa allergy

Question 10

thiazide diuretic side effects

Answer 10

• Hypotension due to volume depletion
• Hypokalemia [impair release of insulin=impair glucose] and hyponatremia
• Hypochloremia
• Hypomagnesemia
• Hypercalcemia (with chronic use)- time dependent= the longer they use it the greater the risk
• Hyperuricemia (with chronic use)- time dependent= the longer they use it the greater the risk
  Thiazide Diuretics Side Effects
• Hyperglycemia-? impaired release of insulin related to hypokalemia?
• Increased total and LDL-cholesterol and triglycerides.
• Rash and photosensitivity- sunburn
• GI disturbances
• Vertigo, headache

Question 11

thiazide diuretics dimish the effects of which drugs

Answer 11

• Anticoagulants
• Uricosuric agents
• Insulin
• Sulfonylureas

Question 12

thiazide diuretics increase the effects of which drugs

Answer 12

• Digitalis aka digoxin
• Lithium
• Loop diuretics