K SPARING DIURETICS - ALDOSTERONE ANTAGONISTS / ANTAGONISTS OF MINERALOCORTICOID RECEPTORS

Question 1

location of action for K sparing diuretic - aldosterone antagonists

Answer 1

collecting duct

Question 2

generic name is spirolactone - what is the route of administration

Answer 2

aldactone- PO

Question 3

uses for K sparing diuretics - aldosterone antagonists

Answer 3

• Edema
• HTN
  *Usually in combo with thiazide or loop for these indications- to help with K loss
• Hyperaldosteronism- drug used to compete with existing aldosterone.
• Adrenal adenoma, adrenal hyperplasia
• Polycystic Ovarian Syndrome [most common clinical use] /Hirsutism/Acne- off label
• By blocking androgen receptors and inhibiting steroid synthesis

Question 4

contraindications for K sparing diuretics - aldosterone antagonists

Answer 4

• hyperkalemia
• peptic ulcer

Question 5

side effects for K sparing diuretics - aldosterone antagonists

Answer 5

• Hyperkalemia – possibly life threatening.
• Due to steroid structure – gynecomastia, impotence, menstrual irregularities
• Diarrhea
• Gastritis
• Gastric bleeding
• Peptic ulcers