K SPARING DIURETICS = INHIBITORS OF RENAL EPITHELIAL Na CHANNELS

Question 1

what are the 2 types of K sparing diuretics

Answer 1

• inhibitors of renal epithelial Na channels
• aldosterone antagonsists - antagonsits of mineralocorticoid receptors

Question 2

generic name is triamterne - what is the route of administration

Answer 2

brand name is dyrenium - PO

Question 3

generic name is triamterene with HCTZ to prevent hyperkalemia - what is the route of administration

Answer 3

brand name is dyazide
brand name is maxzide
both PO

Question 4

generic is amiloride -what is the route of administration

Answer 4

brand name is midamor-PO

Question 5

generic name is amiloride with HCTZ -what is the route of administration

Answer 5

brand name is moduretic - PO

Question 6

uses for K sparing diuretic- inhibitors of renal epithelial Na channels

Answer 6

• Hypertension
• some additive effects noted when used concurrently with thiazides or loop diuretics.
• Treatment of edema
• Used in the treatment or prevention of hypokalemia.
• useful for those not tolerating or not unresponsive to potassium supplements. - thus, sometime Loop is given with K supplements

Question 7

K sparing diuretics- inhibitors of renal epithelial Na channels - contraindications

Answer 7

• Anuria/Renal Failure
• Severe liver disease- affects metabolism of medications.
• Hyperkalemia
• Concomitant use with K+-sparing diuretic, or K supplementation