Therapy For Hypercholesterolemia

Question 1

Low risk < 2 CAD factors

10 Yr cardiac risk <1%

Answer 1

LDL GOAL 190

Question 2

IM=<2 CAD risk factors W NO DM

10 yr cardiac risk 1-10%

Answer 2

LDL GOAL 160

Question 3

High=>2 Risk factors but no know CAD/PVD

10 year cardiac risk 11-20%

Answer 3

LDL GOAL < 100

LDL at drug initiation >130

Question 4

Highest risk Know CAD, PVD, DM, Metabolic Syndrome

10 Year cardiac risk is >20%

Answer 4

LDL GOAL < 100 ***< 70

LDL at drug initiation >100

Question 5

HMG-CoA Reductase Inhibitors 1st line for? and whats RLS?

Answer 5

Statin
Choleesterol reduction
RLS in cholesterol synthesis HmgCoA reductase

Question 6

HMG-CoA Reductase Inhibitors most potent? reduces what risk?

Answer 6

reducing LDL but they also mildly elevates HDL

reduces death from CAD and Stroke

Question 7

HMG-CoA Reductase Inhibitors primary Side Effect

Answer 7

Rhabdomyolsis

Question 8

Fenofibrate function

Answer 8

Raises HDL and lowers TAG

Question 9

Niacin Function and AE?

Answer 9

most effective @ lower TAG and Raising HDL

AE= flushing lessened by TITRATION

Question 10

Which population do you avoid Niacin tx in

Answer 10

Gout and diabetics bc niacin can increase Insulin resistance

Question 11

Ezetimide function

Answer 11

inhibits cholesterol absorption

Question 12

Gemfibrozil function?

NEVER COMBINE with?

Answer 12

Inhibits VLDL production Primary effect in TAG reduction

Never give with Statins bc increase risk of Rhabdo