Therapies

Question 1

An elevated IFP can cause ___________ chemo drug uptake.

Answer 1

decreased

Question 2

Some chemo drugs require oxygen for maximal efficiency so ____________ can cause resistance.

Answer 2

hypoxia

Question 3

A ______ pHe creates a pH gradient across the plasma membrane of cells which presents a barrier to drug delivery for chemo drugs.

Answer 3

low

Question 4

Oxygen is a very potent ____________, well-oxygenated cells require ________ dose of anoxic cells to achieve a given level of cell killing.

Answer 4

radiosensitizer
1/3

Question 5

Response of cells to ionizing radiation is strongly dependent on ___________.

Answer 5

oxygen

Question 5

For most cells OER for x-rays is ________. At dose of <3 Gy, OER is _______. OER for high LET radiation is __________.

Answer 5

2.5-3
reduced
1-1.5

Question 5

The oxygen enhancement ratio (OER) is given by:

Answer 5

OER = (radiation dose in hypoxia) / (radiation dose in air). for the same biological effect.

Question 6

If ___________ occurs between fractions, then radiation killing of initially hypoxic cells will be greater and the hypoxic cells have less impact on response.

Answer 6

re-oxygenation