Chapter 9: Tumor Radiobiology

Question 1

Hypoxia refers to ____________.

Answer 1

lack of oxygen

Question 2

The most important aspect of the tumor microenvironment is __________.

Answer 2

hypoxia

Question 3

Unique characteristics of the tumor microenvironment results from ___________ and __________.

Answer 3

poorly formed tumor vasculature
physiology of tumor cells

Question 4

The three recognized microenvironmental hallmarks of solid tumors are ____________, __________, and ___________. These all contribute to _______________.

Answer 4

high interstitial fluid pressure (IFP)
low oxygen tension or hypoxia
low extracellular pH (pHe)
resistance to chemotherapy

Question 5

________ vessels are more permeable than _______ vessels.

Answer 5

tumor
normal

Question 6

Poor oxygen delivery by defective vasculature and oxygen consumption by tumor cells result in __________.

Answer 6

hypoxic areas

Question 7

Tumor vessels are _______ and _______ with _________ meaning lower mean vascular density.

Answer 7

long
chaotic
unusually large diameter