Therapeutics and Immunology: Lecture 4: Autoimmunity Flashcards
What receptors do steroid hormones and corticosteroids work on
Steroid: Glucocorticoid receptors
Corticosteroids: Mineralocorticoid receptors
What is an endogenous molecule and give an example
Endogenous- something that originates from an organism, tissue or cell
Example: Cortisone
Give an example of a synthetic steroid
Beclometasone dipropionate
What is autoimmunity
Damage caused by an immune mechanism when there is not a hazard from an internal antigen
Unlike hypersensitivity- outside antigen
What is an auto-antigen
Antigen produced in the body that is a good characterisation for each auto immune disease, each has its own specific characterisation for that condition
What are autoimmune diseases and give examples
Range of diseases that are manageable to life threatening- characteristically diverse and variable
Chronic and progressive
Examples: Rheumatoid arthritis and diabetes
Give examples of organ specific autoimmune diseases (8)
Type 1 diabetes mellitus:
acute (all cells die at once in pancreatic islet cells)
Goodpastures syndrome
Multiple sclerosis
Graves disease
Hashmitos thyroiditis
Autoimmune haemolytic anaemia
Autoimmune Addison’s disease Vitiligo
Myasthenia gravis
Give examples of systemic autoimmune diseases
Rheumatoid arthritis- can also affect cardiovascular system
Scleroderma
Systemic lupus erythematosus- attack of healthy cells
What are the auto antigens of multiple sclerosis, type 1 diabetes, rheumatoid arthritis and systemic lupus erythematosus
Type 1 diabets: Pancreatic islet cells
Rheumatoid Arthritis: IgG
Lupus erythematosus: Cell nucleus proteins
What are the three immune interventions in autoimmunity
NO CURE
Block lymphocyte activity
Block inflammation
Treatment and management of symptoms
Based on the three immune interventions, state the 3 specific interventions targets
- Inhibition of antigen specific priming
- Inhibition of antigen specific effector functions
- Method of inflammation and immunopathology
