Therapeutic Potentials Flashcards

1
Q

What are the potential therapeutic uses for MDMA ?

A

PTSD

Antidepressant

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2
Q

What is the mechanism of action of MDMA?

A

Goes through monoamine transporter, blockers VMAT on vesicles and activates TAAR1. PKA/PKC causes internalisation of the transporter. PKC causes reversal

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3
Q

What is the mechanism of action of amphetamine?

A

It enters through monoamine transporters, enters the vesicles through vmat and accumulates. The amine group on amphetamine is basic, and therefore the build up causes disruption of the pH balance, which stops NT entering. It then activates TAAR to cause internalisation or reversal of the receptor

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4
Q

What are the potential therapeutic uses for Amphetamine?

A

ADHD
Antidepressant
Stroke

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5
Q

What is the mechanism of action of cocaine?

A

It blocks the DAT transporter

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6
Q

What is a therapeutic use for cocaine?

A

Nasal surgery

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7
Q

What is a potential therapeutic use of ketamine ?

A

Anaesthetic
Treatment-resistant depression
Pain

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8
Q

What are potential therapeutic uses for cannabis?

A

Decrease N/V in chemotherapy patients
Alleviate chronic pain
Neurological problems such as MS, epilepsy and Huntington’s

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