Addiction Treatments

Question 1

What are some novel addiction treatments ?

Answer 1

• DA receptor partial agonists (D2/3 partial agonists)
• GABA signalling modulators (Baclofen = GABA agonist)
• HPA modulators (CRF1 antagonist, dynorphin antagonist, neurokinin 1 receptor antagonist)
• Glutamate modulators (AMPA/NMDA receptor antagonists, mGluR agonist, mGluR5 antagonist)
• vaccinations (inject abs to bind to substance and stop it passing BBB
• oxytocin (prevent emotional withdrawal/ depression to maybe prevent addiction)