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Dosing Exam 1 > Therapeutic Drug Monitoring > Flashcards

Therapeutic Drug Monitoring Flashcards

1
Q

Therapeutic Drug Monitoring is

A

clinical lab measurments

Drug dosage individualized by PK and PD

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2
Q

Goal of optimal therapeutic effects:

A

target concentration range and context important (treat the pt not the number)

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3
Q

Why TDM?

A

Max efficacy
Minimize toxicity
PK changes
Monitor adherence

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4
Q

Max efficacy involves

A

Can tell if there if a lack of response or change in clinical status

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5
Q

TDM Summary

A

Individualized (uses Pk/PD)
Maximize response
Minimize AE
Context (treat the pt not the number)

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6
Q

AGs

A

Amikacin
Gentamicin
Tobramycin

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7
Q

Anti-epileptic

A

Carbamazepine
Phenytoin
Valproic acid

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8
Q

Anti-coagulants

A

Warfarin/Heparins

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9
Q

Anti-arrhythmics

A

Digoxin Procainamide

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10
Q

Immunosuppressants

A

Cyclosporine

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11
Q

Methylxanthines

A

Theophylline

Caffeine

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12
Q

PD includes

A

Therapeutic effects

AEs

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13
Q

PK =

A

Body effect on the drug

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14
Q

PD =

A

Drug effect on body

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15
Q

Dose –>

A

PK –> PD –> clinical effect or AE

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16
Q

Steps in TDM Process

A

Diagnosis –> Drugs –> Dose –> Drug administered –> pt assessment/drug concentration –> PK/clinical judgement –> dose adjust

17
Q

Communication involves

A

MD or PharmD order
RN administration
Lab collection/phlebotomy
Interpretation

18
Q

Pharmacists can have input

A

Solicited/unsolicited
Chart notes/unofficial notes/verbal discussion
Orders

19
Q

Solicited Communication

A

Know limits
May involve writing orders
Chart documentation
Per MD consult

20
Q

Unsolicited Communication

A 
Know audience
Let them lead
Recommend
Consider
May involve writing orders
21
Q

Both solicited and unsolicited involved?

A

RELATIONSHIPS

22
Q

Components of communication

A 
courteous
professional
factual
key elements included
concise
clean and neat
legible

Dosing Exam 1 (8 decks)

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