Aminoglycosides

Question 1

AG Spectrum of activity =

Answer 1

Gram negative aerobes

Gram positive organisms

Question 2

AGs are used in

Answer 2

Sepsis
Abdominal infxn
Respiratory tract infxn
SSTI
Endocarditis
CNS
UTI

Question 3

AG efficacy is seen through

Answer 3

Peak

Concentration dependent

Question 4

AG minimize toxicity through

Answer 4

troughs

- These drugs have PAE but you don’t want to keep them too low for too long

Question 5

Dosing strategies

Answer 5

Population based

Weight based

Question 6

Ro is

Answer 6

mg/hr

Question 7

Peak are taken

Answer 7

30 minutes post 30 minute infusion

Question 8

Troughs are taken

Answer 8

30 minutes immediately pre-dose

Question 9

Why extended interval dosing?

Answer 9

Concentration dependent killer PAE
Convenience
Less constly

Question 10

Use caution with EI dosing in:

Answer 10

Enterococcal endocarditis
Burns
Renal fialure
Osteomyelitis
Meningitis
Pregnancy
Cf
Febrile neutropenia

Question 11

CrCl + Tau (hrs

Answer 11

Greater than 60 = 24h
40-50 = 36 hrs
20-39 = 48 hrs
Less than 20 = serial levels to determine next dose time

Question 12

Draw concentration is what pts?

Answer 12

Critically ill/comorbidities
Renal function not normal
Long course (adults >3 d or children > 5 d)

Question 13

Follow up concentration in:

Answer 13

extended duration
Scr up or down significantly (~20% change)
Aggressive dosing
Unexpected results