Therapeutic Apheresis Flashcards
Separation principle used in apheresis
Centrifuge into layers and extract what is needed from the blood
Removal of large volumes of patient plasma w/ simultaneous infusion of appropriate replacement fluids
Therapeutic Plasma Exchange (TPE)
Diseases treatable by TPE
- Myasthenia Gravis
- Thrombotic Thombocytopenic Purpura
- AlloAbs in solid organ transplant
- Waldenstrom’s macroglobulinemia
- Focal segmental glomerulosclerosis
RBC Exchange
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Diseases treatble by RBC exchange
- Sickle cell disease
- Thalassemia major
- Protozoal infections: Babesiosis, Plasmodium falciparum
- Incompatible transfusion
- CO poisoning
Cellular depletions
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Diseases treatable by cellular depletions
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System collects the buffy coat from the patient in a continuous flow process and simultaneously (double needle) or intermittently (singl need) and returns the remaining cells to the patient
Extracoporeal photophoresis (ECP)
Diseases treatable by ECP
- Graft vs. Host Disease (GVHD)
- Cutaneous T Lymphoma (CTCL)
Removal of excess iron and red cell mass from body
Therapeutic phlebotomies
Diseases treatable by therapeutic phlebotomies
- Hemochromatosis
- Polycythemia vera (PV)
Intravenous infusion of HSCs collected from the PB which is used to reestablish hematopoietic function following the ablation of a patient’s BM and immune system by chemotherapy
Hematopoietic progenitor cell collection
Diseases treatable by hematopoietic progenitor cell collection
- Multiple myeloma
- Non-Hodgkin Lymphoma
- Germ Cell tumors
- Amyloidosis
What is the appropriate replacement fluid for Thrombotic thrombocytopenic purpura (TTP)?
IV Calcium
