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Liz's Blood Bank Module 2 > Component Preparation > Flashcards

Component Preparation Flashcards

1
Q

What is the role of ATP and 2,3-DPG as it pertains ot RBC survival

A
  • ATP helps RBCs move Na+ and Ca2+ out of the cell

- 2,3-DPG controls hemoglobin affinity for O2

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2
Q

State the primary goal of a RBC perservative

A

To provide 75% survival of transfused blood 24 hours post-transfusion

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3
Q

Changes seen in stored blood

- Plasma K+

A

INCREASED

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4
Q

Changes seen in stored blood

- Plasma Na+

A

DECREASED

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5
Q

Changes seen in stored blood

- Plasma hemoglobin

A

INCREASED

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6
Q

Changes seen in stored blood

- ATP

A

DECREASED

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7
Q

Changes seen in stored blood

- 2,3-DPG

A

DECREASED

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8
Q

Changes seen in stored blood

- pH

A

DECREASED

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9
Q

Expiration date of blood drawn in ACD and CPD

A

21 days

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10
Q

Expiration date of blood drawn in CPDA

A

35 days

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11
Q

Expiration date of blood drawn in AdSol

A

42 days

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12
Q

Centrifugation process when preparing packed RBCs

A

?

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13
Q

Centrifugation process when preparing random platelets

A

?

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14
Q

Centrifugation process of fresh frozen plasma

A

?

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15
Q

Centrifugation process of cryoprecipitate

A

WB → hardspin → plt-poor plasma → freeze plasma → thaw plasma in 1-6°C waterbath → “Cryo” will precipitate in cold → hardspin → remove cryo-poor plasma, leaving cryo precipitate in the bag

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16
Q

Difference b/w components prepared in an “open system” and “closed system”

A

?

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17
Q

Expiration date w/ an open system

A

24 hours

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18
Q

Expiration date w/ a closed system

A

Does not change

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19
Q

Describe the use of a “sterile docking device”

20
Q

Give examples of when a “sterile docking device” is used

21
Q

How does the procedure of a “sterile docking device” affect the expiration of the product?

22
Q

Why do platelet products need constant agitation?

A

To prevent them from clumping

23
Q

How do irradiation of products prevent Graft vs. Host Disease (GVHD)?

A

Irradiation destroys T lymphocyte’s ability to mount an immune response

24
Q

Calculate the enw expiration date when red cell or platelet products are irradiated

25
Q

Proper packing procedure when shipping Red cell products (liquid)

A

Ship w/ “wet ice” or crushed ice, not touching donor units (separated by cardboard)

26
Q

Proper packing procedure when shipping platelet products

A

Ship at room temperature

27
Q

Proper packing procedure when shipping frozen platelet products (FFP, Cryo, frozen cells)

A

Ship w/ dry ice

28
Q

Packed Cells, AdSol

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 42 days
  • Storage temp: 1-6°C
  • Content: RBCs, WBC, ↓ plasma
  • QC: ≤ 80% Hct
  • Indications: Anemia
  • Tx criteria: XM required; ABO-compatible required
29
Q

Leukoreduced packed cells

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 42 days
  • Storage temp: 1-6°C
  • Content: RBCs, ↓ plasma
  • QC: ≤ 80% Hct, < 5x10^6 WBCs
  • Indications: Anemia, hx of febrile rxns
  • Tx criteria: XM required; ABO-compatible required
30
Q

Washed packed cells

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 24 hours
  • Storage temp: 1-6°C
  • Content: RBCs
  • QC: < 5 x 10^6 WBCs
  • Indications: Anemia, IgA deficient patients, removal of K+ and anticoagulant
  • Tx criteria: XM required; ABO-compatible required
31
Q

Frozen cells/Deglyc’d cells

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 10 years frozen/24 hours thawed
  • Storage temp: ≤ -65°C frozen/1-6°C thawed
  • Content: RBCs
  • QC: < 5 x 10^6 WBCs
  • Indications: Anemia, IgA deficient patients, rare units
  • Tx criteria: XM required; ABO-compatible required
32
Q

Random platelets

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 5 days
  • Storage temp: RT w/ agitation
  • Content: Plt, plasma, WBCs
  • QC: ≥ 5.5 x 10^10 plts; ≥ 6.2 pH
  • Indications: Low platelets
  • Tx criteria: ABO-compatible preferred
33
Q

Random platelet, pool

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 4 hours
  • Storage temp: RT w/ agitation
  • Content: Plt, plasma, WBCs
  • QC: ≥ 6.2 pH
  • Indications: Low plts
  • Tx criteria: ABO-compatible preferred
34
Q

Apheresis platelets

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 5 days
  • Storage temp: RT w/ agitation
  • Content: Plt, plasma, WBCs
  • QC: ≥ 3.0 x 10^11 plts; ≥ 6.2 pH
  • Indications: Low plts
  • Tx criteria: ABO-compatible preferred
35
Q

AFFP, FFP, PF24, frozen

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 1 year
  • Storage temp: ≤ -18°C
  • Content: Coagulation clotting factors, plasma
  • QC: N/A
  • Indications: Coagulation factors, liver disease, DIC
  • Tx criteria: ABO-compatible preferred
36
Q

PF24, FFP, thawed

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 5 days
  • Storage temp: 1-6°C
  • Content: stable coag factors
  • QC: N/A
  • Indications: Stable factors, liver disease, DIC
  • Tx criteria: ABO-compatible preferred
37
Q

AFFP, thawed

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 24 hours
  • Storage temp: 1-6°C
  • Content: Labile and stable factors
  • QC: N/A
  • Indications: All coag factors, liver disease, DIC
  • Tx criteria: ABO-compatible preferred
38
Q

Cryo, frozen

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 1 year
  • Storage temp: ≤-18°C
  • Content: Factor VIII, vWF, XIII, fibrinogen
  • QC: ≥ 80 IU VIII; ≥ 150 mg fibrinogen
  • Indications: Hemophilia A, vW disease, XIII deficiency, fibrinogen deficiency, fibrin glue
  • Tx criteria: ABO compatible preferred
39
Q

Cryo, thawed

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 6 hours
  • Storage temp: Room temperature
  • Content: Factor VIII, vWF, XIII, fibrinogen
  • QC: ≥ 80 IU VIII; ≥ 150 mg fibrinogen
  • Indications: Hemophilia A, vW disease, XIII deficiency, fibrinogen deficiency, fibrin glue
  • Tx criteria: ABO compatible preferred
40
Q

Cryo, thawed and pooled

  • Shelf life
  • Storage temp
  • Content
  • QC
  • Indications
  • Tx criteria
A
  • Shelf life: 4 hours
  • Storage temp: Room temperature
  • Content: Factor VIII, vWF, XIII, fibrinogen
  • QC: ≥ 80 IU VIII; ≥ 150 mg fibrinogen
  • Indications: Hemophilia A, vW disease, XIII deficiency, fibrinogen deficiency, fibrin glue
  • Tx criteria: ABO compatible preferred
41
Q

List the anticoagulants that play a part in the survival of donor blood

A
  • Trisodium citrate
  • Citric acid
  • Dextrose
  • Na phosphate
  • Adenine
  • Mannitol
42
Q

What is the function of the anticoagulant trisodium citrate?

A

Binds Ca2+ and prevents clotting

43
Q

What is the function of the anticoagulant citric acid?

A

Maintains pH

44
Q

What is the function of the anticoagulant dextose

A

Provides energy source

45
Q

What is the function of the anticoagulant Na phosphate?

A

Maintains 2,3-DPG levels and ↑ pH

46
Q

What is the function of the anticoagulant adenine?

A

↑ ADP levels which results in synthesis of more ATP

47
Q

What is the function of the anticoagulant mannitol?

A

Protects against spotnaneous storage hemolysis

Liz's Blood Bank Module 2 (8 decks)

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