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Immunology > Therapeutic Antibodies And Clinical Cytokines > Flashcards

Therapeutic Antibodies And Clinical Cytokines Flashcards

1
Q

Aldesleukin (IL-2)

A

Renal cell carcinoma

Metastatic melanoma

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2
Q

Epoetin Alfa (erythropoietin)

A

Anemias (especially in renal failure)

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3
Q

Filgrastim (G-CSF)

A

Recovery of bone marrow and WBC by granulocyte stimulation

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4
Q

Sargramostim (GM-CSF)

A

Recovery of bone marrow and WBC by granulocyte and monocytes stimulation

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5
Q

IFN-alpha

A 
Chronic HBV/HCV
Kaposi sarcoma
Malignant melanoma
Hairy cell leukemia
Condylomata acuminata
Renal cell carcinoma
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6
Q

IFN-beta

A

MS

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7
Q

IFN-gamma

A

Chronic granulomatous disease

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8
Q

Romiplostim (thrombopoietin analog)

A

Thrombocytopenia

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9
Q

Eltrombopag (thrombopoietin receptor agonist)

A

Thrombocytopenia

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10
Q

Oprelvekin (IL11)

A

Thrombocytopenia

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11
Q

Alemtuzamab

A

Target CD52

CLL, MS

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12
Q

Bevacizumab

A

target VEGF
CRC, RCC, non-small cell lung cancer
Neovascular age-related macular degeneration, proliferative diabetic retinopathy, and macular edema

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13
Q

Cetuximab

A

Target EGFR

Stage 4 CRC, head and neck cancer

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14
Q

Rituximab

A

Target CD20

B-cell non-Hodgkin lymphoma, CLL, RA, ITP

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15
Q

Trastuzumab

A

Target HER2/neu

Breast cancer, gastric cancer

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16
Q

Adalimumab

A

Target soluble TNF-alpha

IBD, RA, ankylosis spondylitis, psoriasis

17
Q

Certolizumab

A

Target soluble TNF-alpha

IBD, RA, ankylosis spondylitis, psoriasis

18
Q

Golimumab

A

Target soluble TNF-alpha

IBD, RA, ankylosis spondylitis, psoriasis

19
Q

Infliximab

A

Target soluble TNF-alpha

IBD, RA, ankylosis spondylitis, psoriasis

20
Q

Daclizumab

A 
Target CD25 (part of IL-2 receptor)
Relapsing MS
21
Q

Eculizumab

A

Targets complement protein C5

Paroxysmal nocturnal hemoglobinuria

22
Q

Natalizumab

A

Targets alpha4-integrin (WBC adhesion)
MS, Crohn disease
Risk of PML in patients with JC virus

23
Q

Ustekinumab

A

Targets IL-12/IL-23

Psoriasis, psoriatic arthritis

24
Q

Abciximab

A

Target platelet glycoproteins 2b/3a

Antiplatelet

25
Q

Denosumab

A

Target RANKL

Osteoporosis (inhibits osteoclasts maturation–mimics osteoprotegerin)

26
Q

Digoxin immune Fab

A

Targets digoxin

Antidote

27
Q

Omalizumab

A

Targets IgE

Refractory allergic asthma, prevents IgE binding to Fc-epsilonRI

28
Q

Pavlivizumab

A

Targets RSV F protein

RSV prophylaxis for high-risk infants

29
Q

Ranibizumab

A

targets VEGF

Neovascular age-related macular degeneration, proliferative diabetic retinopathy, and macular edema

Immunology (5 decks)

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