Autoantibodies Flashcards by G Lau

Q

Anti-ACh receptor

A

Myasthenia gravis

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Q

Anti-glomerular basement membrane

A

Goodpasture syndrome

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Q

Anti-beta2 glycoproteins

A

Antiphospholipid syndrome

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Q

Anticardiolipin (lupus anticoagulant)

A

SLE

Antiphospholipid syndrome

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Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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Q

Anti-desmoglein (anti-desmosome)

A

Pemphigus vulgar is

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Q

Anti-glutamic acid decarboxylase

A

DM1

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Q

Islet cell cytoplasmic antibodies

A

DM1

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Q

Anti-hemidesmosome

A

Bulbous pemphigoid

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Q

Anti synthetase (anti-Jo 1)

A

Polymyositis

Dermatomyositis

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Q

Anti-SRP

A

Polymyositis

Dermatomyositis

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Q

Anti-helical (anti-Mi-2)

A

Polymyositis

Dermatomyositis

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Q

Antimicrosomal

A

Hashimoto thyroiditis

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Q

Antithyroglobulin

A

Hashimoto thyroiditis

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Q

TPO antibodies

A

Hashimoto thyroiditis

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Q

Antimitochondrial

A

Primary biliary cirrhosis

Q

Antiparietal cell

A

Pernicious anemia

Q

Anti-IF

A

Pernicious anemia

Q

Antiphospholipase A2 receptor

A

Primary membranous nephropathy

Q

Anti-Scl-70 (anti-DNA topoisomerase 1)

A

Scleroderma (diffuse)

Q

Anti-smooth muscle

A

Autoimmune hepatitis type 1

Q

Anti-SSA (anti-Ro)

A

Sjogren syndrome

Q

Anti-SSB (anti-La)

A

Sjogren syndrome

Q

Anti-TSH receptor

A

Graves’ disease

Anti-presynaptic voltage-gated calcium channel

LEMS

IgA anti-endomysial

Celiac disease

IgA anti-tissue transglutaminase

Celiac disease

MPO-ANCA (p-ANCA)

Microscopic polyangiitis Eosinophilia granulomatosis with polyangiitis (Churg-Strauss) UC

PR3-ANCA (c-ANCA)

Granulomatosis with polyangiitis (Wegener)

RF

IgM Ab against IgG Fc region | RA

Anti-CCP

More specific than RF | RA

Antinuclear (ANA)

Nonspecific, often with SLE

Anti-dsDNA

SLE

Anti-Smith

SLE

Anti-his tone

Drug-induced lupus

Anti-U1 RNP (ribonucleoprotein)

Mixed connective tissue disease