Cytokines

Question 1

IL1

Answer 1

Macrophages

Fever, acute inflammation, adhesion molecules, chemokine

Question 2

IL6

Answer 2

Macrophages
Acute
Fever, acute-phase protein production

Question 3

IL8

Answer 3

Macrophages

Major chemotactic factor for neutrophils

Question 4

IL12

Answer 4

Macrophages

Induces differentiation of T cells into Th1, activates NK cells

Question 5

TNF-alpha

Answer 5

Macrophages
Acute
Activates endothelium, causes WBC recruitment, vascular leak
Causes cache is in malignancy
Maintains granulomas in TB

Question 6

IL2

Answer 6

All T cells

Growth of helper, cytotoxic, and regulatory T cells, and NK cells

Question 7

IL3

Answer 7

All T cells
Supports growth and differentiation of bone marrow stem cells
Functions like GM-CSF

Question 8

Interferon-gamma

Answer 8

Th1 cells
Secreted by NK cells and T cells in response to antigen or IL-12 from macrophages–>stimulates macrophages to kill phagocytosed pathogens
Inhibits differentiation of Th2 cells
Activates NK cells to kill virus-infected cells
Increase MHC/Ag presentation by all cells

Question 9

IL4

Answer 9

TH2
T cells into Th2
Promotes growth of B cells
Enhances class switching to IgE and IgG

Question 10

Il5

Answer 10

TH2
Growth and differentiation of B cells
Class switching to IgA
Stimulates growth and differentiation of eosinophils

Question 11

IL10

Answer 11

Th2
Attenuates inflammatory response
Decrease MHC 2 and Th1 cytokines
Inhibits activated macrophages and dendritic cells
Also secreted by regulatory T cells

Question 12

TGF-beta

Answer 12

Attenuate immune response

Question 13

C5a/IL8/leukotriene B4/kallikrein

Answer 13

Attract neutrophils