Therapeutic Antibodies Flashcards
Alemtuzumab
Target: CD52
Clinical Use: CLL and MS
Bevacizumab
Target: VEGF
Clinical Use: Colorectal Cancer and Renal Cell Carcinoma
Cetuximab
Target: EGFR
Clinical Use: Stage 4 Colorectal Cancer and Head and Neck Cancer
Rituximab
Target: CD20
Clinical Use: B-Cell non-Hodgkin Lymphoma, CLL, Rheumatoid Arthritis, ITP
Trastuzumab
Target: HER2/Neu
Clinical Use: Breast Cancer
Adalimumab
Certolizumab
Infliximab
Target: Soluble TNF-Alpha
Clinical Use: IBD, Rheumatoid Arthritis, Ankylosing Spondylitis Psoriasis
Eculizumab
Target: Complement Protein C5
Clinical Use: Paroxysmal Nocturnal Hemoglobinuria
Natalizumab
Target: Alpha4-Integrin (WBC Adhesion)
Clinical Use: Multiple Sclerosis, Crohn Disease
Risk of PML in patients with JC Virus
Abciximab
Target: Platelet Glycoproteins IIB/IIIA
Clinical Use: Prevention of Ischemic Complications in patients going to the cath lab
Denosumab
Target: RANKL (osteoclast maturation)
Clinical Use: Osteoporosis
Digoxin Immune Fab
Target: Digoxin
Clinical Use: Digoxin Toxicity
Omalizumab
Target: IgE
Clinical Use: Allergic Asthma
Palivizumab
Target: RSV F Protein
Clinical Use: RSV prophylaxis for high-risk infants
Ranibizumab
Bevacizumab
Target: VEGF
Clinical Use: Neovascular Age-Related Macular Degeneration
