theophylline Flashcards
1
Q
give an example
A
xanthine
2
Q
what type of drug is it?
A
a competitive non selective phosphodiesterase inhibitor
3
Q
what is it used in?
A
asthma
STABLE copd
4
Q
mechanism of action
A
works by activating CAMP pathway
inhibiting TNF and leukotriene synthesis therefore reducing inflammatory activity
also antagonises A,1,2,3 receptors therefore explains the cardiac side effects
5
Q
caution in who?
A
[1] elderly [2] those at risk of hypokalaemia [3] CVD patients- hypertension and arrthymias [4] peptic ulcer [5] hyperthyroidism [6] epilepsy
6
Q
SE
A
convulsions tachycardia palpitations nausea vomiting diarrhoea headache insomnia
7
Q
drug interactions
A
additive effect with beta agonists - increase hypokalaemia risk.
