prednisolone

Question 1

what is it?

Answer 1

a corticosteroid

a steroid

Question 2

what is it used to treat?

Answer 2

asthma
copd
anaphylaxis reaction 
polymyalgia rheumatic
giant cell arteritis
myanthesa gravis
IBD 
inflame arthritis
idiopathic thrombocytopenic pupura
cancer -part of some chemotherapy 
hormone replacement in adrenal insufficiency

Question 3

MOA

Answer 3

work by upregulating anti inflam genes and downregulating pro inflam genes
suppression of oesphil and monocytes production

Question 4

used in caution in who?

Answer 4

those with infections

childrens - may stunt growth and reduce response to vaccines

Question 5

AE

Answer 5

[1]
skin thinning, bruising and muscle wasting due to increased catabolism
[2] immunosuppressive - increase risk of infections
[3] metabolic changes - diabetes and osteoporosis
[4] mood changes- psychosis, insomnia
5] ssupress ACTH secretion therefore adrenal atrophy in prolonged use

Question 6

issue with sudden withdrawal?

Answer 6

cv collapse

therefore withdraw slowly

Question 7

interactions

Answer 7

[1] peptic ulcers and bleeds risk increase with NSAIDS
[2] hypokalaemia with b2 agonist, theophylline and or loop diuretics

[3] reduced efficacy due to inhibitor of p450 e.g. phenyotin