Theophylline

Question 1

Theophylline - indication

Answer 1

1) asthma
2) COPD
3) other lung conditions caused by reversible airflow obstruction

Question 2

Theophylline - MOA

DONT NEED TO KNOW FOR EXAM

Answer 2

• inhibits phosphodiesterase (PDE)
• this decreases the hydrolysis of cAMP = increases amount of cAMP
• increases bronchodilation

Question 3

Theophylline - Adverse effects

Answer 3

headache,

nausea, stomach upset, or vomiting

not sleeping well

increased heart rate

skin rash

seizures.

Question 4

Theophylline - contraindications and cautions

Answer 4

Cardiac arrhythmias or other cardiac disease

elderly (increased plasma-theophylline concentration)

epilepsy

hypertension

peptic ulcer; risk of hypokalaemia; thyroid disorder

Question 5

Theophylline - interactions

Answer 5

smoking

b2- agonists

oral corticosteroids

quinolone