Inhaled corticosteroids ICS

Question 1

ICS - Name them

Answer 1

Beclomethasone
Budesonide
Fluticasone

Question 2

ICS - Indications

Answer 2

Asthma: First line preventer

COPD: prevention of exacerbation + symptom control in COPD with ASTHMA (remember: must be combined with LABA)

Question 3

ICS - Side effects

Answer 3

Oral candidiasis (thrush

Hoarse voice

Sore mouth

Temporary change in taste

SHOT

Question 4

ICS - Contrindications (do not use)

Answer 4

none :)

Question 5

ICS - Warnings (use with caution)

Answer 5

High dose ICS:

Can increase risk of Pneumonia : should be used with caution in those with Hx of Pneumonia.

Use with caution in children with risk of growth suppression.

Question 6

MOA

Answer 6

binds to intracellular receptors.
activated receptor enters nucleus affecting the transcription of proteins:

=
Pro-inflammatory proteins are down-regulated.
Anti-inflammatory proteins are up-regulated.

=

1) reduced mucosal inflammation
2) reduced mucus production

= reduced exacerbations + improved symptoms.