The TCA cycle

Question 1

how many reactions are there in the TCA cycle?

Answer 1

8

Question 2

What is the mnemonic for the TCA cycle substrates

Answer 2

A Clown In Kilimanjaro Sings Songs For Money Only

Acetyl CoA, Citrate, Isocitrate, (alpha) Ketoglutarate, Succinyl CoA, Succinate, Fumarate, Malate, Oxaloacetate

Question 3

Acetyl CoA or oxaloacetate -> Citrate + CoA
Enzyme?

Answer 3

Citrate synthase

Question 4

Citrate -> Isocitrate
Enzyme?

Answer 4

Aconitase

Question 5

Isocitrate + NAD+ -> a-ketoglutarate + NADH + CO2
Enzyme?

Answer 5

Isocitrate dehydrogenase

Question 6

a-ketoglutarate + NAD+ + CoA -> succinyl CoA + NADH + CO2
Enzyme?

Answer 6

a-ketoglutarate dehydrogenase

Question 7

Succinyl CoA + GDP + Pi -> Succinate + GTP + CoA
Enzyme?

Answer 7

Succinyl thiokinase

Question 8

Succinate + FAD -> Fumarate + FADH2
Enzyme?

Answer 8

Succinate dehydrogenase

Question 9

Fumarate + H2O -> Malate
Enzyme?

Answer 9

Fumarase

Question 10

Malate + NAD+ -> Oxaloacetate + NADH
Enzyme?

Answer 10

Malate dehydrogenase

Question 11

all enzymes of the TCA cycle are located in the mitochondrial matrix apart from:

Answer 11

succinate dehydrogenase
succinate + FAD -> fumarate + FADH2
integrated into inner membrane (part of complex II)

Question 12

What are the products of each turn of the TCA cycle

Answer 12

2 CO2
3 NADH + H+
1 FADH2
1 GTP