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Blood Bank 2: Summer 2024 > The Red Cell Component > Flashcards

The Red Cell Component Flashcards

1
Q

LRBC

A

Leukoreduced RBCS, meaning that the WBCs have been mostly removed

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2
Q

List blood products

A
  • RBCS
  • Granulocytes
  • Platelets
  • Plasma
  • Cryoprecipitate
  • Clotting factor derivatives
  • Rhogam
  • Immune globulin
  • Anti-sera
  • Albumin
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3
Q

Whole blood shelf life

A

ACD/CPD 21 days

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4
Q

Whole blood volume and storage

A
  • Volume 450-500 ml
  • Store 2-6°C
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5
Q

Whole blood hematocrit

A

~38%

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6
Q

Uses for whole blood

A
  • Volume expansion + oxygen carrying capacity
  • Usually autologous units
  • Research promoting it for emergency situations
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7
Q

Which components in whole blood don’t last long in storage?

A

Platelets, WBCS, and clotting factors

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8
Q

Risk of whole blood transfusion

A

Transfusion associated circulatory overload (TACO)

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9
Q

What is considered “manufacturing” blood products?

A
  • Changing purity/potency
  • Irradiating
  • Aliquot
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10
Q

List steps of whole blood component prep from donation

A
  1. Collect in sterile closed system
  2. Decide what product will be used for
  3. Centrifuge to pack RBCs and leukoreduce overnight
  4. Separate components
  5. Test donor blood for ABO type and virus
  6. Label with ISBT label
  7. Release to inventory for distribution
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11
Q

How to prep platelets and plasma from whole blood donation

A
  • Platelets: cool to RT within 24 hrs
  • Plasma: cool 1-10°C within 8 hrs
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12
Q

How does blood collection apheresis work?

A
  1. Decide product to be collected
  2. Collect in apheresis system with intermmittent or continuous flow centrifugation
  3. Return uncollected components
  4. Test donor blood for ABO type and virus
  5. Label products with ISBT label
  6. Release to inventory for distribution
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13
Q

Different donor requirements for apheresis

A

Require 40% hct and 16 wk deferral

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14
Q

Warm auto-Ab treatment

A

Plasmapheresis

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15
Q

Leukemia treatment

A

Photopheresis

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16
Q

Erythrocytapheresis treatment is for which disease?

A

Sickle cell

17
Q

Apheresis risks

A
  • Citrate toxicity
  • Vascular access
  • Vasophagal reactions
18
Q

LRBC WBC count reduced to _____

A

WBC < 5 X 10^6

19
Q

LRBC shelf life and storage

A
  • shelf life: 21-42 days
  • storage- 2-6°C
20
Q

LRBC desired hct

A

60-85%

21
Q

LRBC risks

A
  • Graft vs host disease
  • Pathogen exposure
22
Q

DRBC (DEGLYCEROLIZED RBCs) prep

A

Wash away plasma proteins, platelets, and WBCs

23
Q

DRBC storage and shelf life

A
  • storage: -65°C
  • frozen shelf life: 10 years
  • freshly washed shelf life: 24 hrs
24
Q

DRBC desired hct

A

70-80%

25
Q

DRBC uses

A
  • Rare antigens
  • Patients with allergic reactions
26
Q

DRBC risks

A
  • Cell degradation
  • Leftover glycerol
  • Bag degradation
27
Q

LIRBC (irradiated and packed RBCs) storage and shelf life

A
  • storage: 2-6°C
  • shelf life: 28 days post irradiation or expiration date, which ever comes first
28
Q

LIRBC uses

A
  • immunocompromised patients
  • babies
29
Q

LIRBC risks

A
  • HLA immunization
  • RBCs higher degradation post-irradiation
30
Q

What does irradiation with 25 Gy do to RBCs?

A

Eliminates T cell mitogenic (cell division) capacity

31
Q

Blood storage in transfusion service vs transfer between sites in/outside hospital

A
  • In transfusion service: 2-6°C
  • In/outside hospital: 1-10°C
32
Q

Explain 30 minute rule

A

Some hospitals limit blood being outside of BB to 30 min

33
Q

Temp outside range will change blood product expiration date to ____

A

4 hrs

34
Q

List when to conduct visual inspection of blood product

A
  • on receipt
  • daily
  • at crossmatch
  • at issue
  • at return
35
Q

Visual inspection

A
  • hemolysis
  • lipemia
  • bacterial contamination
  • particulate matter
  • discoloration
36
Q

Which of the following cannot be kept in the blood bank inventory/storage?
A. blood components that left BB and returned unspiked, 1-10°C
B. Washed DRBCs 25 hr from wash
C. RBC aliquot seal failure < 24h r
D. Blood components outside BB at 2-6°C in validated coolers
E. Blood components transported from vendor/taxi/helicopter/police at 1-10°C

A

B, because DRBCs must be less than 24 hrs old from wash

37
Q

Red blood cell substitutes

A
  • Hemoglobin-based oxygen carrier
  • Perfluorocarbons - can’t actually use
  • RBC engineering to make Type O from any blood type by removing sugars
38
Q

Which product cannot be made from a whole blood donation processed within 24 hr?
A. LRBC
B. Platelets
C. FP24
D. Cryoprecipitate

A

D. Cryoprecipitate because it needs to be made in 8 hrs, not 24 hr

39
Q

Which type of RBC should be given to a patient with known allergic reactions to blood products?
A. DRBC
B. LRBC
C. IRBC
D. Whole blood

A

A. DRBC
It was washed, so allergens in plasma are removed

Blood Bank 2: Summer 2024 (8 decks)

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