The Liver Flashcards
Liver
Largest organ in body, right upper abdominal area, beneath the diaphragm
Functions of the liver
Metabolism, Synthesis, Storage, Detoxification and excretion:
Metabolism
Carbohydrates, protein, and fat delivered through the portal circulation
Synthesis
Plasma proteins, clotting factors
Storage
Vitamin B12 and other materials
Detoxification and excretion
Various substances
Liver’s Blood Supply
Has a double blood supply; Both blood sources mix in the liver, eventually collecting in right and left hepatic veins that drain into inferior vena cava
Portal vein
75% of blood, drains spleen and gastrointestinal tract, rich in nutrients absorbed from intestines, low in oxygen
Hepatic artery
Rest of blood, high in oxygen, low in nutrients
Common types of liver injury
- Viral hepatitis
- Fatty liver
- Alcoholic liver disease or alcoholic hepatitis
- Cirrhosis
Manifestations of Liver Injury
- Cell necrosis
- Fatty change
- Mixed necrosis and fatty change