The inflammatory periodontal lesion #2 Flashcards
- plaque-induced
- inflammation (edema + BOP)
- No destruction of PDL & bone
- No apical migration of epithelial attachment
Gingivitis
Epithelial attachment =
junctional epithelium
- plaque-induced
- inflammation (edema + BOP)
- destruction of bone
- apical migration of epithelial attachment
Periodontitis
What do we mean when we say “periodontitis is host-related”?
susceptibility of host plays a role in progression of gingivitis to periodontitis
What model of disease progression states that “continuous through out life at same rate of loss” i.e. everyone gets perio disease:
continuous model
What model of disease progression states “progressive loss overtime of some sites; no destruction in others; time of onset and extent vary among sites”
Progressive model
saying “periodontal disease affects mainly posterior teeth” would align with:
progresive model
What model of disease progression states “activity occurs at random at any site; some sites show no activity; some sites have one or more bursts of activity; cumulative extent of destruction varies among sites
Random burst model
Saying “periodontitis is different in various sites in the same individual and it is difficult to predict attachment loss” aligns with:
random burst model
What model of disease progression states “several sites have one or more bursts of activity during one period of life; prolonged period of inactivity = remission; cumulative extend of destruction varies among sites; some sites don’t develop attachment loss; bursts due to risk factors:
Asynchronous multiple burst model
What does asynchronous mean in the asynchronous multiple burst model?
not occurring at same time
Signs of inflammation:
- rubor (redness)
- calor (heat)
- dolor (pain)
- tumor (swelling)
- function laesa (loss of function)
Inflammation is a _____ phenomenon
vascular
Inflammation includes what two components?
- Vasculitis
- Leukocyte migration
Describe the components of vasculitis (3)
- dilation
- venous stasis (congestion)
- increased permeability
First defense = _____ immunity
innate
How does innate immunity work?
kills by phagocytosis
What cells are involved in innate immunity?
- PMNs
- Monocytes
- Macrophages
Describe innate immunity:
non-adaptive; genetic
Second defense = _____ immunity
adaptive
How does adaptive immunity work?
production of immunoglobulins by antibodies
What cells are involved in adaptive immunity?
- B-cells
- T- cells
- plasma cells
What are the plasma cells in adaptive immunity responsible for?
produce specific antibodies to individual antigens
Activated B-cells become:
plasma cells
Plasma cells produce:
immunoglobulins
T lymphocytes ar edeveloped in the:
thymus
List the functions of T-lymphocytes
- antigen presentation
- help b-cells divide
- destroy virally infected cells
- can down-regulate immune response
T-cells an differentiate into 2 major forms including:
Cd4 and Cd8 cells
MHC class II molecules =
CD4 cells (helper t-cells)
MHC class I molecules =
CD8 (cytotoxic T-cells)
List the roles of helper T-cells:
- help B cells
- control leukocyte development
- activate innate cell lining
List the roles of cytotoxic T cells:
destroy virally infected target cells
List cells that function in immunity: (4)
- PMNs
- Macrophages
- B- Cells
- T-cells
What immune cell is being described below?
- phagocytosis
- produce lysosomal enzymes
PMNs
What immune cell is being described below?
- phagocytosis
- process antigens
- cytokine secretion
macrophages
What immune cell is being described below?
- produce antibodies
B-cells (plasma cells)
What immune cell is being described below?
- Helps b-cells divide
Helper T cells (CD4)
What immune cell is being described below?
- down-regulates T and B cells
Supressor T-cells (Cd8 & Cd25)
What immune cell is being described below?
- Kills virally-infected cells
Natural Killer T cells (CD56)
What immune cell is being described below?
- Destroys infected cells
Cytotoxic T- cells (Cd8)