Current use of antimicrobials & antibiotics- FINAL Flashcards

1
Q

Chlorhexidine is a ____ charged molecule that binds to the ____ charged sites on the cells wall; it destabilizes the cell wall and interferes with ____

A

postive-charged; negatively-charged; osmosis

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2
Q

Lower concentrations of chlorhexidine leads to:

A

increased permeability and leakage

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3
Q

Higher concentrations of chlorhexidine leads to:

A

precipitation of cytoplasmic contents inducing microbial cell death

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4
Q

List the 3 mechanisms of chlorhexidine:

A
  1. high substantivity
  2. adhere to soft & hard tissues
  3. slow release over 12 hours
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5
Q
  • Bioresorbable polymer with 2.5mg of chlorhexidine
  • inserted into pocket of greater than 5 mm
  • release takes 7 days
  • dissolves on own
  • Significant improvement in CAL when used with SRP
A

periochip

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6
Q
  • 10% doxycycline hyclate
  • delivered sub G with cannula
  • controlled release over 21 days
  • Significant improvement of CAL the used with SRP
A
  • doxycycline hyclate gel
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7
Q
  • 1mg minocycline hydrochloride in bioabsorbale microspheres
  • bacteriostatic by inhibiting protein syntehsis
  • borad spectrum
  • significantly reduced red-complex bacteria in smokers
  • greater improvement in PD & CAL regardless of smoking status
A

Microsphere

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8
Q
  • non reservable monolithic fiber (ethylene vinyl acetate polymer) contains 25% tetracycline powder
  • currently unavailable
  • slow release over 10 days
  • needs removal
  • improves PD, BOP, and CAL when combined with SRP within 6 months
A

tetracycline fiber

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9
Q

Diode laser:

A

soft tissue

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10
Q

Laser used in nonsurgical sulcular debridement in period diseasecontrol

A

NDYAG

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11
Q
A
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