Current use of antimicrobials & antibiotics- FINAL Flashcards
1
Q
Chlorhexidine is a ____ charged molecule that binds to the ____ charged sites on the cells wall; it destabilizes the cell wall and interferes with ____
A
postive-charged; negatively-charged; osmosis
2
Q
Lower concentrations of chlorhexidine leads to:
A
increased permeability and leakage
3
Q
Higher concentrations of chlorhexidine leads to:
A
precipitation of cytoplasmic contents inducing microbial cell death
4
Q
List the 3 mechanisms of chlorhexidine:
A
- high substantivity
- adhere to soft & hard tissues
- slow release over 12 hours
5
Q
- Bioresorbable polymer with 2.5mg of chlorhexidine
- inserted into pocket of greater than 5 mm
- release takes 7 days
- dissolves on own
- Significant improvement in CAL when used with SRP
A
periochip
6
Q
- 10% doxycycline hyclate
- delivered sub G with cannula
- controlled release over 21 days
- Significant improvement of CAL the used with SRP
A
- doxycycline hyclate gel
7
Q
- 1mg minocycline hydrochloride in bioabsorbale microspheres
- bacteriostatic by inhibiting protein syntehsis
- borad spectrum
- significantly reduced red-complex bacteria in smokers
- greater improvement in PD & CAL regardless of smoking status
A
Microsphere
8
Q
- non reservable monolithic fiber (ethylene vinyl acetate polymer) contains 25% tetracycline powder
- currently unavailable
- slow release over 10 days
- needs removal
- improves PD, BOP, and CAL when combined with SRP within 6 months
A
tetracycline fiber
9
Q
Diode laser:
A
soft tissue
10
Q
Laser used in nonsurgical sulcular debridement in period diseasecontrol
A
NDYAG
11
Q
A