THE HERIDITARY MATERIAL Flashcards
who discovered DNA
Friedrich Miescher
How did miescher found a new kind of molecule?
Segregating or isolating nuclei from pus and calling it nuclein
What might the nuclien be involved in functionally?
POTENTIALLY heredity
how many and what 5 kinds of nitrogenous bases did albercht krossel find?
- guanine
- adnenine
- thymine
- cytosine
- uracil
What did Pheobus Levene discover about DNA?
He elucidated the structure of nucleotides and suggested differences between DNA and RNA.
DNA is made up of nucleotides
what was the tetranucleotide hypothesis
DNA consisted of repeating units of 4 nucleotides
What did Archibald Grrod find out?
Alcaptonuria - a genetic disorder where it is hard to break down homogenistic acid leading to the urine turning black and future tissue and muscle problems.
the trait is inherited as a recessive gene
Conclusion: normally allele produces an enzyme to break this acid but the alkaptonuric allele produced a defective enzyme
first instance where a mutation is linked to a biochem pathway
What did Franz Moewus conclude after studying genetics of sexuality in unicellular alga?
Franz Moewus found that when certain genes in the green algae Chlamydomonas were changed (mutated), the algae couldn’t produce sex hormones. This showed that these genes were responsible for making the chemicals (sex hormones). So, if a gene is changed and the organism can’t make a specific chemical, it implies that the gene controls the production of that chemical. This means genes are like instructions for making the chemicals that the body needs to function.
Basically genes = responsible for producing chemicals
What Beadle and Tatum discover about mutants in the fungus?
Each mutant lacked a specific enzyme needed in a biochemical pathway leading to the one gene one enzyme hypothesis
What is the sickle cell amnesia associated with?
A malformed version of a protein, hemoglobin provides a link between genetic mutation and molecular disease
What book did Schrodinger ?
What Is Life
What was talked about in the book what is life?
- studying living matter might reveal unknown laws of physics
- also it was proposed that genes must be made of 100 to 1000 atoms for stability anymore might allow frequent gene destruction due to thermal disruption of covalent bonds.
Each gene is aperiodic crystal that means that every atom or group of atom on it must have specific place and role