The Hepatic and Biliary Systems Flashcards
Describe the pathology of acute viral hepatitis, and name causitive organisms
Hepatocyte necrosis, usually around hepatic veins associated with neutraphil infiltration. Major causitive organisms:
- Hepatitis A & E, B
- CMV
- EBV
What are the non-viral causes of acute hepatitis?
Non viral causes of acute hepatitis include:
- Infection e.g. toxoplasmosis
- Drugs e.g. paracetamol
- Alcohols
- Poisons
- Others: pregnancy, Wilson’s disease
Describe the pathology of chronic hepatitis. What are the main causative organisms of chronic viral hepatitis?
Chronic (>6 month) inflammatory cell infiltrate, comprising plasma cells and sometimes lymphoid follices. There is a varying degree of liver fibrosis, starting around the portal tracts and eventually linking to form nodules.
Causitive organisms:
- Hepatitis B and C
What is the presentation of acute viral hepatitis?
Generally presents with non-specfiic symptoms including:
- Malaise / low grade fever / arthralgia / nausea
- Jaundice (if severe)
- Hepatomegaly (1-2 cm, soft edge)
In the absence of jaundice, acute hepatitis is often diagnoses using liver function tests. What would be the expected findings in levels of:
- Albumin
- AST / ALT
- Bilirubin
- Albumin: Normal
- AST / ALT - Raised due to hepatic necrosis
- Bilirubin - Elevated. In severe acute hepatitis urobilinogen may be absent from urine representing cholestasis, but reappears as hepatitis resolves
The most common cause of viral hepatitis is Hep. A. Describe the clinical features of disease including transmission, incubation period, and clinical signs
- Transmission: fecal-oral, saliva
- Incubation: short (2-3 weeks)
- Clinical symptoms
- nonspecific nausea, and anorexia.
- Jaundice may develop 1 - 2 weeks post-infection
- Urine may become dark and stools pale due to intrahepatic cholestasis
Note: there is no chronic stage in hepatitis A infection - prognosis is good, and infection resolves in 3 - 6 weeks
How is a diagnosis of hepatitis A infection made?
- Anti-HAV IgG antibodies common in geneal population older than 40, an anti-HAV IgM signals acute infection
Hepatitis B is a cause of both acute and chronic hepatitis. Describe the transmission and incubation period of HBV infection
- Transmission: Blood (needlestick injury, IVDU), vertical (mother-child), saliva, sexual contact (particularly male-male)
- Incubation: Long - 1-5 months
Acute HBV may be subclinical, or may produce symtpoms similar to acute HAV infection. However, approximately 10% of patients may progress to a chronic phase. What are the clinical features and investigations performed in chronic hepatitis?
- Clinical features
- May present as mild, slowly progressive hepatitis, or established chronic liver disease
- Increased risk of cirrhosis
- Increased likelihood of hepatocellular carcinoma
- Investigations
- Moderate rise in AST / ALT
- Moderate rise in ALP
- Bilirubin often normal
- HBsAg and HBV DNA often present in serum.
There are several markers that can be used in HBV infection to aid in diagnosis of infection:
- HBsAg - Surface antigen. Present in acute or chronic infection
- HBeAg / HBcAg - HBV ‘Core’ antigen (or the surface form of the antigen, in the case of HBeAg) - indicator of viral replication and continued infectious state of host
- HBV DNA - Implies viral replication
- Anti-HBs - Immunity to HBV, previous exposure or vaccination
- Anti-HBc
- IgM - acute infection
- IgG - past infection (cleared if HBsAg negative)
Describe the transmission, timecourse and clinical presentation of HCV infection
- Transmission: IVDU and unscreened blood products (pre-1990)
- Timecourse - Long - acute hepatitis usually asymptomatic, usually not possible to date start of infection
- Clnical features:
- Often asymptomatic with disease discovered following routince biochemical tests showing ALT elevation
- Progression to chronic liver disease and cirrhosis may occur
When is treatment indicated for chronic hepatitis (either HBV of HCV)
- Evidence of liver damage - cirrhosis, chronic liver failure
- Both have potential to progress to hepatocellular carcinoma - approx 1% p/a with concurrent cirrhosis
What is cirrhosis? Describe the pathogenesis
Cirrhosis results from necrosis of liver cells followed by fibrosis and nodule formation. Diffusely abnormal liver architecture interferes with blood flow and function, leading to portal hypertension and impaired cell function.
Fibrosis results from chronic inflammation and necrosis. It is initiated by stellate cells, a main source of fibrous tissue, and stimulated by Kuppfer and other inflammatory cells.
What are the main causes of cirrhosis?
Most common / Less common
- Alcoholic liver disease
- Hepatitis B or C
- Non-alcoholic fatty liver disease
- Metabolic disorders: Wilson’s disease, hereditary haemochromatosis, alpha-1 anti-trypsin deficiency
- Autoimmune hepatitis
- Primary biliary cirrhosis, primary sclerosing cholangitis
Cirrhosis is often clinically silent until complications develop. Investigations show reduced prothrombin time and abnormal biochemistry, often with a raised ALP in line with cholestasis due to inflammation. What additional tests should be performed to assess severity?
-
Imaging
- Ultrasound may demonstrate change in size and shape, fatty change and fibrosis may produce change in echogenicity.
- CT shows hepatosplenomegaly
- Endoscopy is used for the treatment of varices and portal hypertensive gastropathy
- Liver Biopsy
- Necessary to confirm type and severity of disease. Defined by diffuse nodularity surrounded by fibrous tissue.
What are the main complications of cirrhosis?
- Portal hypertension and gastrointestinal haemorrhage
- Ascites
- Portosystemic encepalopathy
- Hepatocellular carcinoma
- Bacteraemia, infection
- Renal failure
What is the managemet of cirrhosis?
- Treat underlying cause
- 6 monthly ultrasound to detect early development of hepatocellular carcinoma
- Reduced salt intake
- Avoid aspirin and NSAIDS
What is portal hypertension? How are the causes subdivided?
Portal hypertension is raised pressure within the portal vein, caused by resistance to portal flow. Causes may be:
- Pre-hepatic: (blockage of portal vein before liver) portal vein thrombosis
- Intra-hepatic: (distortion of liver architecture) primary biliary cirrhosis, cirrhosis, Budd-Chiari syndrome
- Post-hepatic: (venous blockage outside of liver - rare) right sided heart failure, constrictive pericarditis
What are the clinical features and presenting features of portal hypertension?
Patients are often asymptomatic - the only clinical evidence is splenomegaly and often chronic liver disease. Presenting features include:
- Haematemesis or melaena from rupture of gastro-oesophageal varices of portal hypertensive gastropathy
- Ascites
- Encephalopathy
- Breathlessness due to porto-pulmonary hypertension or hepatopulmonary syndrome